Seth's Wiki - Recent changes [en]

November 2026

Aesetholephews — Wed, 11 Nov 2026 22:40:11 GMT

November 11

SCD Fluid Bolus

Aesetholephews — Wed, 11 Nov 2026 22:29:59 GMT

SCD hemodynamic effects

November 2026

Aesetholephews — Wed, 11 Nov 2026 22:18:57 GMT

November 11

SCD Fluid Bolus

Aesetholephews — Wed, 11 Nov 2026 18:25:26 GMT

SCD hemodynamic effects

October 2026

Aesetholephews — Wed, 11 Nov 2026 14:54:48 GMT

Journal for Obstetric Anesthesia submission requirements

Aesetholephews — Wed, 11 Nov 2026 14:54:14 GMT

Journal for Obstetric Anesthesia submission requirements

Aesetholephews — Wed, 11 Nov 2026 14:49:52 GMT

Created page with "* references follow AMA reference style * All submissions must comply with the reporting guideline appropriate to the study design (see [https://nam11.safelinks.protection.out..."

New page

* references follow AMA reference style
* All submissions must comply with the reporting guideline appropriate to the study design (see [https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.equator-network.org%2F&data=05%7C02%7CD.Barmpoudi%40Elsevier.Com%7C2e0f89e0b6d9468fee6808dee0d40777%7C9274ee3f94254109a27f9fb15c10675d%7C0%7C0%7C639195398430980969%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=%2BU8PCcP6IENohrnz3wROJTBkuaM8MxlUquOBPXx3yt4%3D&reserved=0 EQUATOR Network])
* Each manuscript must comply with the maximum word count specified for its article type. Please note that in-text citations are not included in the word count, and abstract word limits are additional to the main text limits outlined below.
* Authors must indicate the reporting guideline used in the Author Checklist and submit the completed corresponding Standards of Reporting Checklist together with the cover letter at the time of submission.
* STROBE for observational cohort, case-control, and cross-sectional studies
* Formatting requirements are up to 3000 words, up to 40 references, and a maximum of 6 tables and figures combined (supplementary material encouraged). A structured abstract of up to 250 words and highlights are required.
* Submit files with .doc/.docx extensions for Word and .tex for LaTeX files.
* Double-column formatting is only permitted for LaTeX submissions.
* You are required to provide a concise and factual abstract that does not exceed 250 words. The abstract should:
** State the purpose of your paper.
** Outline basic procedures followed.
** Ιnclude your main findings, their statistical significance, where applicable, and your principal conclusions.
** Emphasize new and important aspects of your study or observations.
* Some guidelines re: abstracts:
** Abstracts must be able to stand alone, as abstracts are often presented separately from the article.
** Avoid references. If any are essential to include, ensure that you cite the author(s) and year(s).
** Avoid non-standard or uncommon abbreviations. If any are essential to include, ensure they are defined within your abstract at first mention.

November 2026

Aesetholephews — Wed, 11 Nov 2026 14:40:31 GMT

November 11

October 2026

Aesetholephews — Wed, 11 Nov 2026 14:27:18 GMT

Low vs. High FiO2

Aesetholephews — Wed, 11 Nov 2026 14:21:34 GMT

November 2026

Aesetholephews — Sun, 08 Nov 2026 14:08:21 GMT

Website upgrades

Aesetholephews — Sun, 08 Nov 2026 13:10:58 GMT

Created page with "* Upgrade to the latest media wiki release with the improved UI. * Confirm that there are scheduled backups. * Make a secure area that is protected with a passkey. * Make a la..."

New page

* Upgrade to the latest media wiki release with the improved UI.
* Confirm that there are scheduled backups.
* Make a secure area that is protected with a passkey.
* Make a landing page.
* Figure out how to add diagrams and images.

Teaching Points

Aesetholephews — Wed, 04 Nov 2026 22:32:50 GMT

October 2026

Aesetholephews — Fri, 30 Oct 2026 03:46:48 GMT

Heterodox Hypothesis

November 2026

Aesetholephews — Thu, 29 Oct 2026 21:13:34 GMT

October 2026

Aesetholephews — Thu, 29 Oct 2026 21:06:51 GMT

@@ Line 29: / Line 29: @@
 ===November 11===
-* Outline submission guidelines for IJOA
+* Outlined submission guidelines for IJOA
-* Demo Respiration.AI hardware... Hgb mass loss. IRB approval to NOT use the Neptune. Analyze PACU and volunteer dataset (ataxic breathing, whatever else).
+* Met w/ Derek and Kai. Jonah is in the process of getting hired and can work 8-10 hrs per week. Will need IRB approval only for data that I want to publish.
 * [[SCD Fluid Bolus]] systematic review, e-mailed Emma about IRB stuff
-* Ketamine systematic review
+* Ketamine systematic review. Little bit depressing.
 ===November 20===
-* Ketamine systematic review
+* Ketamine and postpartum/postoperative depression. Explore systematic reviews, assess quality of evidence, relevance, identify areas for future research.
-* Lab website (1 hr)
+* Lab website
-* Read CLASS-D papers (1 hr)
+* Read CLASS-D papers
-* Open and briefly explore CLASS-D data (1 hr) -> 8 hrs total
+* Open and briefly explore CLASS-D data
 ==Ketamine Review==

@@ Line 20: / Line 20: @@
 =SCD hemodynamic effects=
 {| class="wikitable"
 |+ Caption text

@@ Line 29: / Line 29: @@
 ===November 11===
-* Outline submission guidelines for IJOA (15 minutes)
+* Outline submission guidelines for IJOA
-* Flu shot (15 minutes)
+* Demo Respiration.AI hardware... Hgb mass loss. IRB approval to NOT use the Neptune. Analyze PACU and volunteer dataset (ataxic breathing, whatever else).
-* Demo Respiration.AI hardware (1 hr)
+* [[SCD Fluid Bolus]] systematic review, e-mailed Emma about IRB stuff
-* Ketamine systematic review (2.5 hr)
+* Ketamine systematic review
-* SCD-PV systematic review, IRB stuff (1 hr)
 * Lab website (1 hr)
 * Read CLASS-D papers (1 hr)
 * Open and briefly explore CLASS-D data (1 hr) -> 8 hrs total

@@ Line 17: / Line 17: @@
 * Cardiogenic pulmonary edema
 * Tricuspid regurgitation
 =SCD hemodynamic effects=
@@ Line 41: / Line 42: @@
 |-
 | [https://pubmed.ncbi.nlm.nih.gov/18219162/ Sohn et al Circulation J 2008] || Example || Example || Example || Example
 |}

@@ Line 5: / Line 5: @@
 *Submit a manuscript for publication
 **<s>Meet w/ Nina</s>
-**<s>Identify two journals (plan A and plan B) to submit Brandon's study to.</s> Understand their submission requirements. <s>Write up the introduction for the study in LaTeX</s>, formatted and tailored appropriately for each journal.
+**<s>Identify two journals (plan A and plan B) to submit Brandon's study to. Understand their submission requirements. Write up the introduction for the study</s> in LaTeX, formatted and tailored appropriately for each journal.
 ***[[A&A submission requirements]]
 ***[[Journal for Obstetric Anesthesia submission requirements]]

← Older revision		Revision as of 14:54, 11 November 2026
Line 16:		Line 16:
	** Avoid references. If any are essential to include, ensure that you cite the author(s) and year(s).		** Avoid references. If any are essential to include, ensure that you cite the author(s) and year(s).
	** Avoid non-standard or uncommon abbreviations. If any are essential to include, ensure they are defined within your abstract at first mention.		** Avoid non-standard or uncommon abbreviations. If any are essential to include, ensure they are defined within your abstract at first mention.
		+	* You are required to provide 1 to 7 keywords for indexing purposes.
		+	* You are encouraged to provide a graphical abstract at submission. The graphical abstract summarizes the contents of your article in a concise, pictorial, professional form, highlighting important aspects of the research. It is designed to appeal to an interdisciplinary audience and draw more attention to your online article. Ensure the image is at least 1328 pixels wide, with the longest side horizontal, and is readable at a width of 13 cm. Preferred file types for graphical abstracts are TIFF, EPS, PDF, or MS Office files.
		+	* All artwork must have a caption. A caption should consist of a brief title (not displayed on the figure itself) and a description of the image. Keep the amount of text to a minimum, though any symbol or abbreviation should be explained.
		+	* The introduction should clearly state the objectives of your work. We recommend that you provide an adequate background to your work but avoid writing a detailed literature overview or summary of your results.
		+	* The methods section should provide sufficient details about your materials and methods to allow your work to be reproduced by an independent researcher. Some guidelines:
		+	** If the method you used has already been published, provide a summary and reference the originally published method.
		+	** If you are quoting directly from a previously published method, use quotation marks and cite the source.
		+	** Describe any modifications that you have made to existing methods.

← Older revision		Revision as of 14:40, 11 November 2026
(One intermediate revision by the same user not shown)
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	** Paralyze the worms and then see if you can teach them something (e.g. to associate a sound or light with an aversive stimulus)		** Paralyze the worms and then see if you can teach them something (e.g. to associate a sound or light with an aversive stimulus)
	** Repeat the experiment with propofol, which we know decreases locomotion.		** Repeat the experiment with propofol, which we know decreases locomotion.
		+
		+	===November 11===
		+	* Outline submission guidelines for IJOA (15 minutes)
		+	* Flu shot (15 minutes)
		+	* Demo Respiration.AI hardware (1 hr)
		+	* Ketamine systematic review (2.5 hr)
		+	* SCD-PV systematic review, IRB stuff (1 hr)
		+	* Lab website (1 hr)
		+	* Read CLASS-D papers (1 hr)
		+	* Open and briefly explore CLASS-D data (1 hr) -> 8 hrs total

@@ Line 13: / Line 13: @@
 *Submit RISE 1 application
 **<s>Narrow down research directions and goals</s>
-**Literature review to refine research aims
+**<s>Literature review to refine research aims</s>
 **<s>Identify mentors and institutional resources</s>
 *Identify additional funding sources and apply

@@ Line 3: / Line 3: @@
 * Extubation practices vary, but one common practice is to remove PEEP, and turn FiO2 to 100%.
 * This practice is associated with worsened post-extubation atelectasis and end-expiratory lung volumes (EELV) according to a 2026 BJA paper from a team at BIDMC who used EIT to measure atelectasis and lung volumes. Conversely, using an FiO2 of 40% or 70% was shown to decrease atelectasis and increase EELV.
 https://journals.lww.com/anesthesia-analgesia/fulltext/10.1213/ane.0000000000004374~when-less-is-more-why-extubation-with-less-than-routine-100
 https://journals.lww.com/anesthesiology/fulltext/10.1097/aln.0000000000004654~extubation-with-reduced-inspiratory-oxygen-concentration-or

← Older revision		Revision as of 14:08, 8 November 2026
Line 17:		Line 17:
	**Update faculty profile		**Update faculty profile
	**Timeline for matching MD/PhD students		**Timeline for matching MD/PhD students
		+
		+	==Weekly Summaries==
		+	===November 5===
		+	* Took the day off.
		+	* Teasing out the appropriate interpretation of behavioral screening assays for ''C. elegans''. How do you differentiate if a drug effect is analgesic, paralytic, sedative/hypnotic, or amnestic?
		+	** Can they be paralyzed with rocuronium? Would it be fatal?
		+	** Do worms sleep? When? How long? How do you know? What are several ways you might wake them up?
		+	** What are some learning/memory assays in worms that don't require movement?
		+	** Paralyze the worms and then see if you can teach them something (e.g. to associate a sound or light with an aversive stimulus)
		+	** Repeat the experiment with propofol, which we know decreases locomotion.

← Older revision		Revision as of 22:32, 4 November 2026
(One intermediate revision by the same user not shown)
Line 14:		Line 14:
	* [https://pmc.ncbi.nlm.nih.gov/articles/PMC12998346/ Remimazolam targets]: the theoretical initial target concentration of remimazolam may be 0.1 µg/mL for light sedation, 0.2 µg/mL for moderate sedation, and 0.3 µg/mL for deep sedation in elderly patients (70 years), and 1.5 or 2 times those concentrations in middle-aged (45 years) or young adult (20 years) patients. Dose adjust upwards by 10% in females, down by 20% in obesity or ASA III/IV.		* [https://pmc.ncbi.nlm.nih.gov/articles/PMC12998346/ Remimazolam targets]: the theoretical initial target concentration of remimazolam may be 0.1 µg/mL for light sedation, 0.2 µg/mL for moderate sedation, and 0.3 µg/mL for deep sedation in elderly patients (70 years), and 1.5 or 2 times those concentrations in middle-aged (45 years) or young adult (20 years) patients. Dose adjust upwards by 10% in females, down by 20% in obesity or ASA III/IV.
	* [[Perioperative HTN]]		* [[Perioperative HTN]]
		+	* [https://www.cureus.com/articles/241346-comparison-of-different-weight-scalars-to-dose-sugammadex-for-the-reversal-of-neuromuscular-blockade-in-morbidly-obese-patients-a-systematic-review#!/ Sugammadex dosing in obesity]

@@ Line 28: / Line 28: @@
 ===10/6 Summary===
 *Pitched multi-centre trial to Brandon. E-mailed slides in .ppt format to Nina.
-*Met w/ Norm about depression research (Brian Mickey and Grace Lee) and promotion requirements (Harriet Hopf). '''Need to read this paper about ketamine having an active metabolite that sticks around, explaining its sustained antidepressant effects''' ([https://scholar.googleusercontent.com/scholar.bib?q=info:oxmvfF2RMfcJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuUERc:ACTRDVEAAAAAas-SCRfDvqsYSFStZqKmI5mpZP0&scisig=ACTRDVEAAAAAas-SCWl_hrwNxs7LrCdW_sSZWZk&scisf=4&ct=citation&cd=-1&hl=en Nature paper]).
+*Met w/ Norm about depression research (Brian Mickey and Grace Lim) and promotion requirements (Harriet Hopf). '''Need to read this paper about ketamine having an active metabolite that sticks around, explaining its sustained antidepressant effects''' ([https://scholar.googleusercontent.com/scholar.bib?q=info:oxmvfF2RMfcJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuUERc:ACTRDVEAAAAAas-SCRfDvqsYSFStZqKmI5mpZP0&scisig=ACTRDVEAAAAAas-SCWl_hrwNxs7LrCdW_sSZWZk&scisf=4&ct=citation&cd=-1&hl=en Nature paper]).
 *Lit review of Yohimbine and Naloxone effects on EEG.
 *Dug through supplement of 2026 A&A paper to find which anesthetics are most selective for which receptors ''in vitro''.
@@ Line 37: / Line 37: @@
 *Attended SandLab meeting.
 *Called Christian (consistently has Wed/Thu off, added me to two IRB protocols after I uploaded CITI competency to ERICA system)
-*COMPASS protocol we do need to consent patients (what is it?)
+*COMPASS protocol we do need to consent patients
 *Cameron Jacobson added access to local SAND lab web disk.
 *GitHub can pull functions to work on data from the web disk. Srdjan added me to the main branch.
@@ Line 152: / Line 152: @@
 ===EEG Approach===
-*Emergence from different anesthetics in patients with SEEG implants. Can we correlate this with fMRI and scalp EEG or eCOG?
+*Can we correlate DECODE data with fMRI or eCOG?
-*'''Is emergence just induction backwards? If not, what can that tell you about mechanisms?'''
+*Emergence is not just induction backwards. There's neural inertia and hysteresis. What can this tell you about mechanisms of different agents?
 ===Phylogenetic Approach===
@@ Line 162: / Line 162: @@
 ===Heterodox Hypothesis===
 *If you can anesthetize single-celled organisms, are circuits irrelevant?
-*Hamilton has a gap junction (network of gap junctions?) and some specific neurons that he think are a conserved mechanism of anesthesia. He wants to test this by doing a screen of a bunch of different anesthetics in WT and KO worms with a behavioral screening assay. He has a behavior rig that basically automatically records swimming speed. He wants to look for the EC50 of various anesthetics and see if that number is shifted with KO or KD of different gap junctions.
+*Hamilton has a gap junction (network of gap junctions?) and some specific neurons that he think are a conserved mechanism of anesthesia. He wants to test this by doing a screen of a bunch of different anesthetics in WT and KO worms with a behavioral screening assay. He wants to look for the EC50 of various anesthetics and see if that number is shifted with KO or KD of different gap junctions.
 *Worms natively have a blue-light rhodopsin that triggers an aversion response where they turn around and go the opposite direction.
-*I am going to '''read up on propofol mechanisms in worms, and gap junctions''' before our next meeting on 10/29.
+*'''Read up on gap junctions'''.
 ==DECODE==

← Older revision		Revision as of 21:13, 29 October 2026
(2 intermediate revisions by the same user not shown)
Line 1:		Line 1:
−	*Talk to Emma about process of getting IRB approval for ~~alpha entrainment~~ study	+	'''Lab Vision'''
−	*~~Ingest first case~~	+	We explore mechanisms whereby anesthetics lead to amnesia, hypnosis (i.e. impaired behavioral responsiveness), immobility, and analgesia. We develop pharmacologic and device-based methods to modulate components of anesthesia non-invasively.
		+
		+	'''AY '26-'27 Goals → November Goals'''
		+	*Submit a manuscript for publication
		+	**Methohexital data sharing agreement or IRB
		+	**Ketamine systematic review with Grace/Brian
		+
		+	*Submit RISE 1 application
		+	**Read CLASS-D papers from Christian
		+	**Start mining the CLASS-D dataset
		+	**Talk to Emma about process of getting IRB approval for a study
		+
		+	*Identify additional funding sources and apply
		+	*Start recruiting a research team
		+	**Lab website
		+	**Update faculty profile
		+	**Timeline for matching MD/PhD students

@@ Line 7: / Line 7: @@
 **<s>Identify two journals (plan A and plan B) to submit Brandon's study to.</s> Understand their submission requirements. <s>Write up the introduction for the study in LaTeX</s>, formatted and tailored appropriately for each journal.
 ***[[A&A submission requirements]]
-**Feasability study of SCD-PV
+***[[Journal for Obstetric Anesthesia submission requirements]]
 **<s>Lit review and, if novel</s>, data sharing agreement for Methohexital
@@ Line 13: / Line 14: @@
 **<s>Narrow down research directions and goals</s>
 **Literature review to refine research aims
-**Identify mentors and institutional resources
+**<s>Identify mentors and institutional resources</s>
 *Identify additional funding sources and apply
 *Start recruiting a research team
-==10/2 Summary==
+==Weekly Summaries==
 *E-mailed slides to Nina and followed up on study. It is currently paused due to a hyperbaric PF bupivacaine shortage at OHSU.
 *Texted Brandon about which journals to submit to. 1st choice: A&A, 2nd choice: Journal for Obstetric Anesthesia
@@ Line 24: / Line 26: @@
 *Hamilton and I talked about why ketamine causes lasting changes in the brain long after the drug is gone. Is it a change to a gap junction network? '''Is it anti-inflammatory circulating EVs?'''. There are three papers on MedLine related to ketamine and EVs, none of which look at (anti-)inflammatory molecules. '''Do circulating EVs after propofol anesthetic also contain the inflammatory cytokines that are seen after isoflurane?'''
-==10/6 Summary==
+===10/6 Summary===
 *Pitched multi-centre trial to Brandon. E-mailed slides in .ppt format to Nina.
 *Met w/ Norm about depression research (Brian Mickey and Grace Lee) and promotion requirements (Harriet Hopf). '''Need to read this paper about ketamine having an active metabolite that sticks around, explaining its sustained antidepressant effects''' ([https://scholar.googleusercontent.com/scholar.bib?q=info:oxmvfF2RMfcJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuUERc:ACTRDVEAAAAAas-SCRfDvqsYSFStZqKmI5mpZP0&scisig=ACTRDVEAAAAAas-SCWl_hrwNxs7LrCdW_sSZWZk&scisf=4&ct=citation&cd=-1&hl=en Nature paper]).
@@ Line 32: / Line 34: @@
 *[https://pmc.ncbi.nlm.nih.gov/articles/PMC12998346/ Remimazolam targets]: the theoretical initial target concentration of remimazolam may be 0.1 µg/mL for light sedation, 0.2 µg/mL for moderate sedation, and 0.3 µg/mL for deep sedation in elderly patients (70 years), and 1.5 or 2 times those concentrations in middle-aged (45 years) or young adult (20 years) patients. Dose adjust upwards by 10% in females, down by 20% in obesity or ASA III/IV.
-==10/14 Summary==
+===10/14 Summary===
 *Attended SandLab meeting.
 *Called Christian (consistently has Wed/Thu off, added me to two IRB protocols after I uploaded CITI competency to ERICA system)
@@ Line 46: / Line 48: @@
 *IARS abstract submission deadline is 12/6 (methohexital, ketamine depression, SCD-PV)
-==10/20 Summary==
+===10/20 Summary===
 *Reached out to Houman re: Methohexital data. Lit review of methoxital going back to 1992.
 *Figured out software and access: web disk (use ethernet, VPN, or eduroam), GitHub repos, EEGLAB, MatLab, Anaconda
@@ Line 55: / Line 57: @@
 *Submitted NIH Bio Sketch and project summary for possible matching with MSARF student next summer.
-==10/29 Plan==
+===10/29 Summary===
 *Requested key for desk and put my name up
 *Touched base with Grace about retrospective ketamine study
@@ Line 62: / Line 64: @@
 *Meeting w/ Kai Kuck re: SCD-PV.
 *Meeting w/ Hamilton re: mechanistic studies in worms
-*Meeting w/ Christian re: research directions
+*Meeting w/ Christian re: research directions, RISE application (he's going to send his)
 *Edit and format CS study in LaTeX
@@ Line 127: / Line 129: @@
 **Hamilton is going to start thinking about how to record behavior from multiple wells at once, or how to automate serial well acquisition.
 **I should start by making agar, isolating and plating ''E. coli'' colonies, picking worms, mastering worm husbandry, and acquiring images of WT behaviors.
 **Hamilton is doing a screen of ketamine and isoflurane and trying to get genetic lines to test the relevant receptors.
@@ Line 164: / Line 167: @@
 ==DECODE==
 *SEEG-electrodes allow us to collect LFP along the whole lead, individual neuron firing at the tips.
 *MER (microelectrode recording) switches are where single neurons (at the tips of the electrodes) switch from a state of firing to not firing or vice versa. Coby is trying to see if information from LFPs and EEG can predict when this transition occurs.
@@ Line 183: / Line 187: @@
 ==SWARM==
 *Slow wave analysis and applied morphology
 ==CLAN==
-===Alpha entrainment analgesia study===
+===Nociception Signatures in EEG===
 *Successfully entrain alpha.
 **What were we doing wrong?
 **'''Is there anything in the literature that can guide a protocol modification?'''
 **'''Systematic review and meta analysis'''
-**Can we leverage Ripple hardware/BATMAN (lab-grade, non-FDA approved device) to entrain or modulate alpha band?
+**Use Ripple hardware/BATMAN (lab-grade, non-FDA approved device) to do a sweep of different entrainment techniques in sedated ICU patients to find the best settings/timing.
 *Can I incorporate pain/withdrawal thresholds since everyone's pain tolerance might be different.
 *Make it multi-center
@@ Line 196: / Line 209: @@
 *Power analysis based on pilot study
 *Stimulation of inhibitory neurons in the ACC expressing channelrhodopsin-2 resulted in a reduction of reflexive acute pain responses in mice.
 ===EEG effects of anesthetic agents===
@@ Line 264: / Line 274: @@
 ==Young Blood==
-*Observational study
+*Observational study, talk to Chuck.