Muscle Relaxants
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| Muscle Relaxant | Type | Chemistry | Dose | Onset | Duration | Elimination | Clinical Considerations |
|---|---|---|---|---|---|---|---|
| RocurONium | NDMR | Aminosteroid | 0.45-0.9 mg/kg | 0.5-1.5 min | 30-60 min | Hepatic (70%), Renal (10%) | Workhorse, weak vagolytic effect |
| Cis-atracurium | NDMR | Benzylisoquinolinium | 0.15-0.2 mg/kg | 1.5-2 min | 55-65 min | Hofmann (77%), Renal (16%) | +Laudanosine, Histamine release |
| PancurONium | NDMR | Aminosteroid | 0.1 mg/kg | 4-5 min | 45-65 min | Renal (80%) | Vagolytic effect (sympathomimetic) |
| Atracurium | NDMR | Benzylisoquinolinium | 0.5-0.6 mg/kg | 3-4 min | 20-35 min | Hofmann, ester hydrolysis | ++Laudanosine, Histamine release |
| Succinylcholine | Depolarizing | 1-1.5 mg/kg | 0.5-1 min | 4-6 min | Plasma pseudocholinesterase | RSI, many contraindications |