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→Most Common Etiologies
=Most Common Etiologies=
=Most Common Etiologies=
* '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm
* '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm
=Pathogenesis=
* Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)
* Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)
* Consumption of clotting factors
* Consumption of clotting factors
* Platelets are trapped in the clots
* Platelets are trapped in the clots
* Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]].
* Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]].
=Diagnostic Algorithm=
=Diagnostic Algorithm=
Score of 5+ points strongly associated with DIC=
Score of 5+ points strongly associated with DIC=