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→Melatonin
=Melatonin=
=Melatonin=
Melatonin is a chronohypnotic that decreases firing rate of neurons in SCN via MT1 receptor, but only when endogenous levels are low (i.e. daytime). In older adults, the amount of MT synthesized and the number and affinity of MT1 receptors all decrease. Does not make you feel drowsy. It enhances natural sleep wake cycle. Must be paired with good sleep hygiene. Only need very small amounts (1 mg). Give 1 hr before bedtime. The body makes 1 mg per day, at higher doses exogenous melatonin might decrease your body's ability to synthesize it on its own. Higher doses in the short term show a dose dependent effect, but this wears off quickly and then melatonin stops working at all.
Melatonin is a chronohypnotic that is secreted by the pineal gland and decreases firing rate of neurons in SCN via MT1 receptor. Normal peak serum concentrations are 60 pg/ml. Less than 1 mg is synthesized per day. In older adults, the amount of MT synthesized and the number and affinity of MT1 receptors all decrease. Does not make you feel drowsy. It enhances natural sleep wake cycle. Must be paired with good sleep hygiene. Only need very small amounts (1 mg). Give 1 hr before bedtime. The body makes 1 mg per day, at higher doses exogenous melatonin might decrease your body's ability to synthesize it on its own. Higher doses in the short term show a dose dependent effect, but this wears off quickly and then melatonin stops working at all.
* Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab. 2001 Oct;86(10):4727-30. doi: 10.1210/jcem.86.10.7901. PMID: 11600532.
* Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab. 2001 Oct;86(10):4727-30. doi: 10.1210/jcem.86.10.7901. PMID: 11600532.