Line 5: |
Line 5: |
| Systematic review of 116 included studies between 1978 and 2014. | | Systematic review of 116 included studies between 1978 and 2014. |
| | | |
− | ==DIAGNOSIS==
| + | =DIAGNOSIS= |
− | * Laboratory testing cannot distinguish between asymptomatic colonization and | + | * Laboratory testing cannot distinguish between asymptomatic colonization and active infection. |
− | ¿Eyed frat' cuitisten a forfindsfficile. The best test performance characteristics
| + | ==Diagnostic criteria== |
− | ===Diagnostic criteria===
| |
| * Diarrhea | | * Diarrhea |
− | * Positive stool test for toxigenic C. diff or toxins or pseudomembranous colitis | + | * Positive stool test for toxigenic C. diff or toxins or visualization of pseudomembranous colitis |
− | ===Diagnostic approaches===
| + | ==Diagnostic approaches== |
| * Toxigenic Culture (TC) and/or Cell Cytotoxicity Assay (CCA) | | * Toxigenic Culture (TC) and/or Cell Cytotoxicity Assay (CCA) |
| ** Anaerobic culture for 24-48 hrs followed by colony selection and culture with human cells to test for cell cytotoxicity which takes an additional 24-48 hours. | | ** Anaerobic culture for 24-48 hrs followed by colony selection and culture with human cells to test for cell cytotoxicity which takes an additional 24-48 hours. |
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| * Both positive = C. diff | | * Both positive = C. diff |
| * Both negative = NO C. diff | | * Both negative = NO C. diff |
− | * Mixed results, use PCR for tedB as tiebreaker | + | * Mixed results, use PCR for tcdB as tiebreaker |
| ** Toxin EIA 1 (Meridian), higher PPV, lower NPV | | ** Toxin EIA 1 (Meridian), higher PPV, lower NPV |
| ** Toxin EIA 2 (TechLab), lower PPV, higher NPV | | ** Toxin EIA 2 (TechLab), lower PPV, higher NPV |