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→Neuropsychiatric Disorders
=Neuropsychiatric Disorders=
=Neuropsychiatric Disorders=
==Dementia==
==Dementia==
*H&P:
*H&P:
*Dx:
*Dx: Differentiate from MCI (which has less severe symptoms that do not interfere with ADLs). Differential includes [[Alzheimer disease]] (most common), Parkinson disease, Lewy body dementia, '''frontotemporal dementia (Pick disease)''', vascular dementia, and [[Creutzfeld Jacob disease]] (prions). Check for '''reversible causes''' (TSH, B12, B6, urine tox screen, EtOH levels, infectious workups, depression screen).
*Tx:
*Tx: Based on etiology. '''AChE inhibitors: donepezil, rivastigmine, galantamine.''' Memantine ('''NMDA antagonist'''). Assisted living and social support.
==Wernicke-Korsakoff Syndrome==
==Wernicke-Korsakoff Syndrome==
*H&P:
*H&P: History of heavy EtOH use. Vitamin B1 (thiamine) deficiency.
*Dx:
*Dx: MRI shows atrophy of mammary bodies. EtOH level. Presents with ataxia, '''ophthalmoplegia''', confusion, confabulation, retrograde amnesia. Differential includes NPH.
*Tx:
*Tx: High dose thiamine. Electrolyte repletion. Multivitamin. CIWA protocol for EtOH withdrawal.