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→PSC
==PSC==
==PSC==
*H&P: Age 30-40; M>F; associated with IBD (UC>Crohn's); asymptomatic or presenting with fatigue, pruritic, RUQ pain
*H&P: Age 30-40; M>F; associated with IBD (UC>Crohn's); asymptomatic or presenting with fatigue, pruritic, RUQ pain
*Dx: Elevated ALK and bili, '''ANA, anti smooth muscle, anti pANCA''' antibodies.
*Dx: Elevated ALK + bili, '''ANA, anti smooth muscle, anti pANCA''' antibodies.
*Tx: Ursodeoxycholic acid, cholestyramine, fat-soluble vitamins; transplant '''frequently''' required
*Tx: Ursodeoxycholic acid, cholestyramine, fat-soluble vitamins; transplant '''frequently''' required