*H&P: '''Intrahepatic''' bile duct '''destruction'''; Age 30-65; F>M; Fatigue and jaundice; pruritis and osteoporosis; associated with hypothyroid and arthritis
*H&P: '''Intrahepatic''' bile duct '''destruction'''; Age 30-65; F>M; Fatigue and jaundice; pruritis and osteoporosis; associated with hypothyroid and arthritis
−
*Dx: Elevated ALK + bili; '''positive AMA'''
+
*Dx: Elevated ALK + bili; '''positive AMA'''; no bile duct dilation on imaging
*Tx: Ursodeoxycholic acid, cholestyramine, fat-soluble vitamins; transplant in rare cases
*Tx: Ursodeoxycholic acid, cholestyramine, fat-soluble vitamins; transplant in rare cases