DIC - Revision history

Aesetholephews: /* Diagnostic Algorithm */

2022-10-23T16:23:03Z

Diagnostic Algorithm

Aesetholephews: /* Diagnostic Algorithm */

2022-10-23T16:22:39Z

Diagnostic Algorithm

Aesetholephews: /* Most Common Etiologies */

2022-10-21T22:57:12Z

Most Common Etiologies

Aesetholephews: /* Pathogenesis */

2022-10-21T18:38:25Z

Pathogenesis

Aesetholephews: /* Pathogenesis */

2022-10-21T05:31:09Z

Pathogenesis

Aesetholephews: /* Diagnostic Algorithm */

2022-10-21T05:30:40Z

Diagnostic Algorithm

Aesetholephews: /* Most Common Etiologies */

2022-10-21T05:30:28Z

Most Common Etiologies

Aesetholephews: Created page with "=Most Common Etiologies= * '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn,..."

2022-10-21T05:30:11Z

Created page with "=Most Common Etiologies= * '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn,..."

New page

=Most Common Etiologies=
* '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm
Pathogenesis
* Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)
* Consumption of clotting factors
* Widespread micro and macrovascular thrombosis, depletion of fibrinogen and fibrin clot formation
* Platelets are trapped in the clots
* Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]].
=Diagnostic Algorithm=
Score of 5+ points strongly associated with DIC=
* Presence of a disease known to be associated with DIC (2 pts)
* Platelets < 100k (1 pt), < 50k (2 pt)
* Fibrin degradation products (FDPs) (e.g. d-dimer): moderate increase (2 pt), strong increase (3 pt)
* PT > 3s (1 pt), > 6s (2 pt)
* Fibrinogen < 1 g/L (1 pt)
=Treatments=
* Basically don't get it.
* Treat underlying condition
* Treatment is lousy. Evidence behind treatment is likewise lousy.
* Platelets, cryo, FFP
=Mortality=
*20-50%

@@ Line 16: / Line 16: @@
 * Fibrinogen < 1 g/L (1 pt)
-Compared with the non-DIC group, the DIC group had prolonged K time, decreased α angle, increased R value, and decreased CI and MA value (P<0.05). With increase of SOFA scores, R value and K value increased significantly, and α angle, MA value, and CI decreased significantly (P<0.05). According to TEG, platelet function and fibrinogen function of DIC patients were significantly reduced, and the body showed hypocoagulability.
+Compared with the non-DIC group, the DIC group had prolonged K time, decreased α angle, increased R value, and decreased CI and MA value (P<0.05). With increase of SOFA scores, R value and K value increased significantly, and α angle, MA value, and CI decreased significantly (P<0.05). According to TEG, platelet function and fibrinogen function of DIC patients were significantly reduced, and the body showed hypocoagulability. (PMID: 30988714)
 =Treatments=

@@ Line 1: / Line 1: @@
 =Most Common Etiologies=
 * '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm
 =Pathogenesis=
 * '''Exposure''': Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)

@@ Line 2: / Line 2: @@
 * '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm
 =Pathogenesis=
-* Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)
+* '''Exposure''': Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)
-* Consumption of clotting factors
+* '''Coagulation''': Consumption of clotting factors; Widespread micro and macrovascular thrombosis, depletion of fibrinogen and fibrin clot formation; Platelets are trapped in the clots
-* Widespread micro and macrovascular thrombosis, depletion of fibrinogen and fibrin clot formation
+* '''Fibrinolysis''': Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]] such as D-dimer. Leads to worsened bleeding.
 =Diagnostic Algorithm=

@@ Line 6: / Line 6: @@
 * Widespread micro and macrovascular thrombosis, depletion of fibrinogen and fibrin clot formation
 * Platelets are trapped in the clots
-* Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]].
+* Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]] such as D-dimer.
 =Diagnostic Algorithm=

@@ Line 9: / Line 9: @@
 =Diagnostic Algorithm=
-Score of 5+ points strongly associated with DIC=
+Score of 5+ points strongly associated with DIC
 * Presence of a disease known to be associated with DIC (2 pts)
 * Platelets < 100k (1 pt), < 50k (2 pt)
@@ Line 15: / Line 15: @@
 * PT > 3s (1 pt), > 6s (2 pt)
 * Fibrinogen < 1 g/L (1 pt)
 =Treatments=
 * Basically don't get it.