October 2026 - Revision history

Aesetholephews: /* 10/14 Summary */

2026-10-15T17:58:35Z

10/14 Summary

2026-10-15T17:31:57Z

10/14 Summary

2026-10-15T01:00:18Z

10/14 Summary

2026-10-15T00:55:22Z

10/14 Summary

2026-10-14T21:00:12Z

Non Receptor-Mediated Hypothesis

2026-10-14T20:58:48Z

Phylogenetic Approach

2026-10-14T20:57:28Z

Promiscuous Molecular Targets

2026-10-14T20:54:32Z

2026-10-14T20:52:40Z

2026-10-14T20:47:53Z

10/14 Summary

@@ Line 49: / Line 49: @@
 **Uploaded CITI competency to ERICA system, CC'd Christian
 **Meet next Tuesday to demo Ripple hardware with live intra-op recordings.
-**EEG workshop at February meeting. Christian will send 16 PEACE competencies to start prepping. We could either split it up to each do 8 (preferable), or we could cover all 16, but on different devices.
+**EEG workshop at February meeting. Christian shared 16 PEACE competencies to start prepping. We could either split it up to each do 8 (preferable), or we could cover all 16, but on different devices.
 *Reached out to Grace about ketamine research (OB vs. general surgery population, decreasing incidence of postpartum/post-op depression w/ single dose of ketamine).

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 **GitHub can pull functions to work on data from the web disk. '''Ask Srdjan to add me to the main branch.'''
 **FAER, IARS, RISE. Kristen Kinjo added me to her list to inform of possible funding opportunities.
-**'''Upload CITI competency to Erika system, CC: Christian'''
+**Uploaded CITI competency to ERICA system, CC'd Christian
 **Meet next Tuesday to demo Ripple hardware with live intra-op recordings.
 **EEG workshop at February meeting. Christian will send 16 PEACE competencies to start prepping. We could either split it up to each do 8 (preferable), or we could cover all 16, but on different devices.

@@ Line 46: / Line 46: @@
 **Need access to files. Figure out how to connect to VPN and '''ask Cameron Jacobson for access to local SAND lab web disk'''.
 **GitHub can pull functions to work on data from the web disk. '''Ask Srdjan to add me to the main branch.'''
-**FAER, IARS, RISE. Amy Monroe may have other opportunities. Asked her to add me to her list.
+**FAER, IARS, RISE. Kristen Kinjo added me to her list to inform of possible funding opportunities.
 **'''Upload CITI competency to Erika system, CC: Christian'''
 **Meet next Tuesday to demo Ripple hardware with live intra-op recordings.

@@ Line 48: / Line 48: @@
 **FAER, IARS, RISE. Amy Monroe may have other opportunities. Asked her to add me to her list.
 **'''Upload CITI competency to Erika system, CC: Christian'''
-**Meet next Tuesday to demo ripple hardware with live intra-op recordings.
+**Meet next Tuesday to demo Ripple hardware with live intra-op recordings.
-**EEG workshop at February meeting. Christian will send 16 Delphi competencies to start prepping. We could either split it up to each do 8 (I think preferable), or we could cover all 16, but on different devices.
+**EEG workshop at February meeting. Christian will send 16 PEACE competencies to start prepping. We could either split it up to each do 8 (preferable), or we could cover all 16, but on different devices.
 *Reached out to Grace about ketamine research (OB vs. general surgery population, decreasing incidence of postpartum/post-op depression w/ single dose of ketamine).

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 **Has anyone published behavioral assays for these organisms? How do you make an argument that a slime mold has been anesthetized?
-===Non Receptor-Mediated Hypothesis===
+===Heterodox Hypothesis===
 *Hamilton has a gap junction (network of gap junctions?) and some specific neurons that he think are a conserved mechanism of anesthesia. He wants to test this by doing a screen of a bunch of different anesthetics in WT and KO worms with a behavioral screening assay. He has a behavior rig that basically automatically records swimming speed. He wants to look for the EC50 of various anesthetics and see if that number is shifted with KO or KD of different gap junctions.
 *Worms natively have a blue-light rhodopsin that triggers an aversion response where they turn around and go the opposite direction.

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 ===Phylogenetic Approach===
-*Are there organisms that are resistant to anesthetics? Search for 'weird' organisms that might yield something interesting. Prokaryotes (bacteria, archaea) and Eukaryotes (Protists, Plants, Animals, Fungi). Single cellular and multicellular organisms. What is different about them?
+*Are there organisms that are resistant to anesthetics? Search for 'weird' organisms that might yield something interesting. Prokaryotes (bacteria, archaea) and Eukaryotes (Protists, Plants, Animals, Fungi). Single cellular and Multicellular organisms. For resistant organisms, what is different about them?
 **Downsides of using 'weird' organisms is that there are relatively few genetic tools, antibodies, sparse literature, and few experts to consult.
-**Has anyone published behavioral assays for these organisms? Detailed protocols for breeding them? Have they already been anesthetized?
+**Has anyone published behavioral assays for these organisms? How do you make an argument that a slime mold has been anesthetized?
 ===Non Receptor-Mediated Hypothesis===

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 **Meet w/ Nina
 **Identify two journals (plan A and plan B) to submit Brandon's study to. Understand their submission requirements. Write up the introduction for the study in LaTeX, formatted and tailored appropriately for each journal.
-**SCD-PV?
+**Feasability study of SCD-PV
-**Methohexital?
+**Lit review and, if novel, data sharing agreement for Methohexital
 *Submit RISE 1 application
 **Narrow down research directions and goals
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 **Identify mentors and institutional resources
 *Identify additional funding sources and apply
 *Start recruiting a research team

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 We explore mechanisms whereby anesthetics lead to amnesia, hypnosis (i.e. impaired behavioral responsiveness), immobility, and analgesia. We develop pharmacologic and device-based methods to modulate components of anesthesia non-invasively.
-'''AY '26-'27 Goals'''
+'''AY '26-'27 Goals → October Goals'''
 *Submit a manuscript for publication
 **Meet w/ Nina

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 **'''Read all about GABA receptors in Principles of Neural Science'''
 **Optogenetics can control the activity of a genetically defined set of neurons to see if they are important for your topic of interest. e.g. express anion-conducting channelrhodopsins (ACRs, an inhibitory type of ChR) in α1β2γ2 GABA-R expressing neurons.
-***Could we use optogenetics to clarify whether certain non-canonical propofol targets receptors (e.g. α4β2 nAChR, HCN1) are necessary or sufficient for its effects?
+***Could we use optogenetics to clarify whether certain non-canonical propofol target receptors (e.g. α4β2 nAChR, HCN1) are necessary or sufficient for its effects?
 ***Assuming that α1β2γ2 GABA<sub>A</sub>R is the critical receptor, can we demonstrate which circuits play a critical role? As a starting point (from Brown's Part I):
 ## Excitatory cortical pyramidal neurons