September 2026 - Revision history

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@@ Line 28: / Line 28: @@
 **20 years ago he licensed some PK/PD software to GE but no one bought it. A Norwegian company tried the same thing, also without success. He is now trying to get it integrated into EPIC. Is it just a marketing problem that no one wants to buy it? They've shown that it changes how people deliver anesthesia (typically they use less, specifically opioid).
 **He thinks the big thing that is lacking from Christian's research is volunteer studies.
 *Read through the RISE application.

@@ Line 42: / Line 42: @@
 ***What is the disease burden of depression in the general surgical population? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c14%7c1&Counter5=SS_view_found_complete%7c40404498%7cmedall%7cmedline%7cmed29&Counter5Data=40404498%7cmedall%7cmedline%7cmed29 BJA article] that finds 20% burden of depression in the surgical patients during the pre-op period. They also note that patients have a 2.5x higher risk of non-home discharge. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c16%7c1&Counter5=SS_view_found_complete%7c41495495%7cmedall%7cmedline%7cmed29&Counter5Data=41495495%7cmedall%7cmedline%7cmed29 2026 systematic review and meta-analysis] showing that about 1/4 of surgical cancer patients have depression. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c19%7c1&Counter5=SS_view_found_complete%7c41337802%7cmedall%7cmedline%7cmed29&Counter5Data=41337802%7cmedall%7cmedline%7cmed29 2026 Journal of Clinical Neuroscience] article showed a 4-fold increase in risk of re-operation in ACDF patients who were depressed.
 ***What is the incidence of post-operative depression in general surgical patients without pre-existing depression? What if they have a family or personal history of depression?
-***Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c2%7c1&Counter5=SS_view_found_complete%7c42657795%7cmedall%7cmedline%7cmedl&Counter5Data=42657795%7cmedall%7cmedline%7cmedl RCT happening in China right now]. Another RCT done in China with 142 cardiac surgery patients showed [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c23%7c1&Counter5=SS_view_found_complete%7c41285329%7cmedall%7cmedline%7cmed28&Counter5Data=41285329%7cmedall%7cmedline%7cmed28 significantly decreased post-operative depression] in patients who got a single dose of ketamine (0.3 mg/kg) at induction.
+***Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c2%7c1&Counter5=SS_view_found_complete%7c42657795%7cmedall%7cmedline%7cmedl&Counter5Data=42657795%7cmedall%7cmedline%7cmedl RCT happening in China right now]. Another RCT done in China with 142 cardiac surgery patients showed [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c23%7c1&Counter5=SS_view_found_complete%7c41285329%7cmedall%7cmedline%7cmed28&Counter5Data=41285329%7cmedall%7cmedline%7cmed28 significantly decreased post-operative depression] in patients who got a single dose of ketamine (0.3 mg/kg) at induction. After reviewing the first 51 results on Ovid Medline, I saved selected abstracts to Box.
 **CLAN
 ***When combined with SEEG electrodes or data from Parkinson's patients with deep-brain stimulators, can we resolve temporal and spatial activity of deep subcortical structures with ICA from frontal or full EEG? [https://pubmed.ncbi.nlm.nih.gov/28575667/ steerable non-invasive DBS]

@@ Line 39: / Line 39: @@
 *Feasibile and high-impact research ideas:
-**[Intra-op Treatment and Prophylaxis Against Depression]
+**[[Intra-op Treatment and Prophylaxis Against Depression | Depression]]
 ***What is the disease burden of depression in the general surgical population? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c14%7c1&Counter5=SS_view_found_complete%7c40404498%7cmedall%7cmedline%7cmed29&Counter5Data=40404498%7cmedall%7cmedline%7cmed29 BJA article] that finds 20% burden of depression in the surgical patients during the pre-op period. They also note that patients have a 2.5x higher risk of non-home discharge. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c16%7c1&Counter5=SS_view_found_complete%7c41495495%7cmedall%7cmedline%7cmed29&Counter5Data=41495495%7cmedall%7cmedline%7cmed29 2026 systematic review and meta-analysis] showing that about 1/4 of surgical cancer patients have depression. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c19%7c1&Counter5=SS_view_found_complete%7c41337802%7cmedall%7cmedline%7cmed29&Counter5Data=41337802%7cmedall%7cmedline%7cmed29 2026 Journal of Clinical Neuroscience] article showed a 4-fold increase in risk of re-operation in ACDF patients who were depressed.
 ***What is the incidence of post-operative depression in general surgical patients without pre-existing depression? What if they have a family or personal history of depression?

@@ Line 39: / Line 39: @@
 *Feasibile and high-impact research ideas:
-**Depression
+**[Intra-op Treatment and Prophylaxis Against Depression]
 ***What is the disease burden of depression in the general surgical population? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c14%7c1&Counter5=SS_view_found_complete%7c40404498%7cmedall%7cmedline%7cmed29&Counter5Data=40404498%7cmedall%7cmedline%7cmed29 BJA article] that finds 20% burden of depression in the surgical patients during the pre-op period. They also note that patients have a 2.5x higher risk of non-home discharge. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c16%7c1&Counter5=SS_view_found_complete%7c41495495%7cmedall%7cmedline%7cmed29&Counter5Data=41495495%7cmedall%7cmedline%7cmed29 2026 systematic review and meta-analysis] showing that about 1/4 of surgical cancer patients have depression. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c19%7c1&Counter5=SS_view_found_complete%7c41337802%7cmedall%7cmedline%7cmed29&Counter5Data=41337802%7cmedall%7cmedline%7cmed29 2026 Journal of Clinical Neuroscience] article showed a 4-fold increase in risk of re-operation in ACDF patients who were depressed.
 ***What is the incidence of post-operative depression in general surgical patients without pre-existing depression? What if they have a family or personal history of depression?

@@ Line 42: / Line 42: @@
 ***What is the disease burden of depression in the general surgical population? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c14%7c1&Counter5=SS_view_found_complete%7c40404498%7cmedall%7cmedline%7cmed29&Counter5Data=40404498%7cmedall%7cmedline%7cmed29 BJA article] that finds 20% burden of depression in the surgical patients during the pre-op period. They also note that patients have a 2.5x higher risk of non-home discharge. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c16%7c1&Counter5=SS_view_found_complete%7c41495495%7cmedall%7cmedline%7cmed29&Counter5Data=41495495%7cmedall%7cmedline%7cmed29 2026 systematic review and meta-analysis] showing that about 1/4 of surgical cancer patients have depression. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c19%7c1&Counter5=SS_view_found_complete%7c41337802%7cmedall%7cmedline%7cmed29&Counter5Data=41337802%7cmedall%7cmedline%7cmed29 2026 Journal of Clinical Neuroscience] article showed a 4-fold increase in risk of re-operation in ACDF patients who were depressed.
 ***What is the incidence of post-operative depression in general surgical patients without pre-existing depression? What if they have a family or personal history of depression?
-***Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c2%7c1&Counter5=SS_view_found_complete%7c42657795%7cmedall%7cmedline%7cmedl&Counter5Data=42657795%7cmedall%7cmedline%7cmedl RCT happening in China right now]. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c23%7c1&Counter5=SS_view_found_complete%7c41285329%7cmedall%7cmedline%7cmed28&Counter5Data=41285329%7cmedall%7cmedline%7cmed28 prior RCT with 142 patients] done in China that showed significantly decreased post-operative depression in patients who got a single dose of ketamine (0.3 mg/kg) at induction.
+***Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c2%7c1&Counter5=SS_view_found_complete%7c42657795%7cmedall%7cmedline%7cmedl&Counter5Data=42657795%7cmedall%7cmedline%7cmedl RCT happening in China right now]. Another RCT done in China with 142 cardiac surgery patients showed [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c23%7c1&Counter5=SS_view_found_complete%7c41285329%7cmedall%7cmedline%7cmed28&Counter5Data=41285329%7cmedall%7cmedline%7cmed28 significantly decreased post-operative depression] in patients who got a single dose of ketamine (0.3 mg/kg) at induction.
 **CLAN
 ***When combined with SEEG electrodes or data from Parkinson's patients with deep-brain stimulators, can we resolve temporal and spatial activity of deep subcortical structures with ICA from frontal or full EEG? [https://pubmed.ncbi.nlm.nih.gov/28575667/ steerable non-invasive DBS]