Difference between revisions of "Muscle Relaxants"
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! Muscle Relaxant !! Dose !! Onset !! Duration !! Elimination !! Clinical Considerations | ! Muscle Relaxant !! Dose !! Onset !! Duration !! Elimination !! Clinical Considerations | ||
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| − | | RocurONium || 0.45-0.9 mg/kg || 0.5-1.5 min|| 30-60 min || Hepatic (70%), Renal (10%) || Workhorse, weak vagolytic effect | + | | RocurONium || 0.45 - 0.9 mg/kg || 0.5-1.5 min|| 30-60 min || Hepatic (70%), Renal (10%) || Workhorse, weak vagolytic effect |
|- | |- | ||
| − | | Cis-atracurium || 0.15-0.2 mg/kg || 1.5-2 min || 55-65 min || Hofmann (77%), Renal (16%) || +Laudanosine, Histamine release | + | | Cis-atracurium || 0.15 - 0.2 mg/kg || 1.5-2 min || 55-65 min || Hofmann (77%), Renal (16%) || +Laudanosine, Histamine release |
|- | |- | ||
| PancurONium || 0.1 mg/kg || 4-5 min || 45-65 min || Renal (80%) || Vagolytic effect (sympathomimetic) | | PancurONium || 0.1 mg/kg || 4-5 min || 45-65 min || Renal (80%) || Vagolytic effect (sympathomimetic) | ||
|- | |- | ||
| − | | Atracurium || 0.5-0.6 mg/kg || 3-4 min || 20-35 min || Hofmann, ester hydrolysis || ++Laudanosine, Histamine release | + | | Atracurium || 0.5 - 0.6 mg/kg || 3-4 min || 20-35 min || Hofmann, ester hydrolysis || ++Laudanosine, Histamine release |
|- | |- | ||
| − | | Succinylcholine || 1-1.5 mg/kg || 0.5-1 min || 4-6 min || Plasma pseudocholinesterase || RSI, many contraindications | + | | Succinylcholine || 1 - 1.5 mg/kg || 0.5-1 min || 4-6 min || Plasma pseudocholinesterase || RSI, many contraindications |
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Revision as of 21:31, 31 January 2023
| Muscle Relaxant | Dose | Onset | Duration | Elimination | Clinical Considerations |
|---|---|---|---|---|---|
| RocurONium | 0.45 - 0.9 mg/kg | 0.5-1.5 min | 30-60 min | Hepatic (70%), Renal (10%) | Workhorse, weak vagolytic effect |
| Cis-atracurium | 0.15 - 0.2 mg/kg | 1.5-2 min | 55-65 min | Hofmann (77%), Renal (16%) | +Laudanosine, Histamine release |
| PancurONium | 0.1 mg/kg | 4-5 min | 45-65 min | Renal (80%) | Vagolytic effect (sympathomimetic) |
| Atracurium | 0.5 - 0.6 mg/kg | 3-4 min | 20-35 min | Hofmann, ester hydrolysis | ++Laudanosine, Histamine release |
| Succinylcholine | 1 - 1.5 mg/kg | 0.5-1 min | 4-6 min | Plasma pseudocholinesterase | RSI, many contraindications |