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Adrenergic Pharmacology (view source)
Revision as of 22:47, 1 February 2023
, 22:47, 1 February 2023Created page with "{| class="wikitable" |+ Adrenergic Receptors |- ! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists |- | Alpha-1 || Norepi > Epi >> Iso || Smooth..."
{| class="wikitable"
|+ Adrenergic Receptors
|-
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists
|-
| Alpha-1 || Norepi > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG
|
*Norepi
*Phenylephrine
*Midodrine
|
*Phenoxybenzamine
*Phentolamine
*Prazosin
*Tamsulosin
*Trazodone
|-
| Alpha-2 || Epi = Norepi >> Iso || Mixed effects || Gi, presynaptic, cAMP down
|
*Dexmedetomidine
*Clonidine
|
*Phenoxybenzamine
*Phentolamine
*Trazodone
|-
| Beta-1 || Iso > Norepi > Epi || Example || Gs, cAMP up
|
*Dobutamine
*Isoprenaline
*Norepi
|
'''Cardiac Selective:'''
*Metoprolol
*Atenolol
*Esmolol
|-
| Beta-2 || Iso > Epi > Norepi || Example || Gs, cAMP up
|
'''Non-Selective:'''
*Albuterol
*Formoterol
*Isoprenaline
*Salmeterol
*Terbutaline
*Ritodrine
|
*Propranolol
*Nadolol
*Pindolol
*Timolol
|-
| Beta-3 || Iso > Epi = Norepi || Example || Gs, cAMP up
|
*Mirabegron
|
Example
|}
|+ Adrenergic Receptors
|-
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists
|-
| Alpha-1 || Norepi > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG
|
*Norepi
*Phenylephrine
*Midodrine
|
*Phenoxybenzamine
*Phentolamine
*Prazosin
*Tamsulosin
*Trazodone
|-
| Alpha-2 || Epi = Norepi >> Iso || Mixed effects || Gi, presynaptic, cAMP down
|
*Dexmedetomidine
*Clonidine
|
*Phenoxybenzamine
*Phentolamine
*Trazodone
|-
| Beta-1 || Iso > Norepi > Epi || Example || Gs, cAMP up
|
*Dobutamine
*Isoprenaline
*Norepi
|
'''Cardiac Selective:'''
*Metoprolol
*Atenolol
*Esmolol
|-
| Beta-2 || Iso > Epi > Norepi || Example || Gs, cAMP up
|
'''Non-Selective:'''
*Albuterol
*Formoterol
*Isoprenaline
*Salmeterol
*Terbutaline
*Ritodrine
|
*Propranolol
*Nadolol
*Pindolol
*Timolol
|-
| Beta-3 || Iso > Epi = Norepi || Example || Gs, cAMP up
|
*Mirabegron
|
Example
|}