Difference between revisions of "Adrenergic Pharmacology"
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(Created page with "{| class="wikitable" |+ Adrenergic Receptors |- ! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists |- | Alpha-1 || Norepi > Epi >> Iso || Smooth...") |
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| Beta-2 || Iso > Epi > Norepi || Example || Gs, cAMP up | | Beta-2 || Iso > Epi > Norepi || Example || Gs, cAMP up | ||
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| − | |||
*Albuterol | *Albuterol | ||
*Formoterol | *Formoterol | ||
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*Ritodrine | *Ritodrine | ||
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| + | '''Non-Selective:''' | ||
*Propranolol | *Propranolol | ||
*Nadolol | *Nadolol | ||
Revision as of 22:47, 1 February 2023
| Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
|---|---|---|---|---|---|
| Alpha-1 | Norepi > Epi >> Iso | Smooth muscle contraction | Gq, PLC -> IP3/DAG |
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| Alpha-2 | Epi = Norepi >> Iso | Mixed effects | Gi, presynaptic, cAMP down |
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| Beta-1 | Iso > Norepi > Epi | Example | Gs, cAMP up |
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Cardiac Selective:
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| Beta-2 | Iso > Epi > Norepi | Example | Gs, cAMP up |
|
Non-Selective:
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| Beta-3 | Iso > Epi = Norepi | Example | Gs, cAMP up |
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Example |