Difference between revisions of "Adrenergic Pharmacology"
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| Line 4: | Line 4: | ||
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists | ! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists | ||
|- | |- | ||
| − | | | + | | α1 || Norepi > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG |
| | | | ||
*Norepi | *Norepi | ||
| Line 16: | Line 16: | ||
*Trazodone | *Trazodone | ||
|- | |- | ||
| − | | | + | | α2 || Epi = Norepi >> Iso || Mixed effects || Gi, presynaptic, cAMP down |
| | | | ||
*Dexmedetomidine | *Dexmedetomidine | ||
| Line 25: | Line 25: | ||
*Trazodone | *Trazodone | ||
|- | |- | ||
| − | | | + | | β1 || Iso > Norepi > Epi || Chronotropy, Inotropy, Amylase secretion || Gs, cAMP up |
| | | | ||
*Dobutamine | *Dobutamine | ||
| Line 36: | Line 36: | ||
*Esmolol | *Esmolol | ||
|- | |- | ||
| − | | | + | | β2 || Iso > Epi > Norepi || Smooth muscle relaxation || Gs, cAMP up |
| | | | ||
*Albuterol | *Albuterol | ||
| Line 50: | Line 50: | ||
*Pindolol | *Pindolol | ||
*Timolol | *Timolol | ||
| + | *Carved'''ilol''' (anti-α1) | ||
| + | *Labet'''alol''' (anti-α1) | ||
|- | |- | ||
| − | | | + | | β3 || Iso > Epi = Norepi || Lipolysis, bladder detrusor relaxation || Gs, cAMP up |
| | | | ||
*Mirabegron | *Mirabegron | ||
| | | | ||
| − | + | *SR 59230A | |
|} | |} | ||
Revision as of 23:00, 1 February 2023
| Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
|---|---|---|---|---|---|
| α1 | Norepi > Epi >> Iso | Smooth muscle contraction | Gq, PLC -> IP3/DAG |
|
|
| α2 | Epi = Norepi >> Iso | Mixed effects | Gi, presynaptic, cAMP down |
|
|
| β1 | Iso > Norepi > Epi | Chronotropy, Inotropy, Amylase secretion | Gs, cAMP up |
|
Cardiac Selective:
|
| β2 | Iso > Epi > Norepi | Smooth muscle relaxation | Gs, cAMP up |
|
Non-Selective:
|
| β3 | Iso > Epi = Norepi | Lipolysis, bladder detrusor relaxation | Gs, cAMP up |
|
|