Difference between revisions of "Adrenergic Pharmacology"

Revision as of 23:05, 1 February 2023

Adrenergic Receptors
Receptor	Binding Affinity	Effects	Mechanism	Agonists	Antagonists
α1	Norepi > Epi >> Iso	Smooth muscle contraction	Gq, PLC -> IP3/DAG	Norepi Phenylephrine Midodrine	α1 selective: Prazosin Tamsulosin
α2	Epi = Norepi >> Iso	Mixed effects	Gi, presynaptic, cAMP down	Dexmedetomidine Clonidine	Non-selective: Phenoxybenzamine Phentolamine Trazodone
β1	Iso > Norepi > Epi	Chronotropy, Inotropy, Amylase secretion	Gs, cAMP up	Dobutamine Isoprenaline Norepi	Cardiac Selective: Metoprolol Atenolol Esmolol
β2	Iso > Epi > Norepi	Smooth muscle relaxation	Gs, cAMP up	Albuterol Formoterol Isoprenaline Salmeterol Terbutaline Ritodrine	Non-Selective: Propranolol Nadolol Pindolol Timolol Carvedilol (anti-α1) Labetalol (anti-α1)
β3	Iso > Epi = Norepi	Lipolysis, bladder detrusor relaxation	Gs, cAMP up	Mirabegron	SR 59230A

@@ Line 10: / Line 10: @@
 *Midodrine
 |
-*Phenoxybenzamine
+'''&alpha;1 selective:'''
-*Phentolamine
 *Prazosin
 *Tamsulosin
-*Trazodone
 |-
 | &alpha;2 || Epi = Norepi >> Iso || Mixed effects || Gi, presynaptic, cAMP down
@@ Line 21: / Line 19: @@
 *Clonidine
 |
+'''Non-selective:'''
 *Phenoxybenzamine
 *Phentolamine