Difference between revisions of "Adrenergic Pharmacology"
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| Line 4: | Line 4: | ||
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists | ! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists | ||
|- | |- | ||
| − | | α1 || | + | | α1 || NE > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG |
| | | | ||
| − | * | + | *NE |
*Phenylephrine | *Phenylephrine | ||
*Midodrine | *Midodrine | ||
| Line 14: | Line 14: | ||
*Tamsulosin | *Tamsulosin | ||
|- | |- | ||
| − | | α2 || Epi = | + | | α2 || Epi = NE >> Iso || Mixed effects || Gi, presynaptic, cAMP down |
| | | | ||
*Dexmedetomidine | *Dexmedetomidine | ||
| Line 24: | Line 24: | ||
*Trazodone | *Trazodone | ||
|- | |- | ||
| − | | β1 || Iso > | + | | β1 || Iso > NE > Epi || Chronotropy, Inotropy, Amylase secretion || Gs, cAMP up |
| | | | ||
*Dobutamine | *Dobutamine | ||
| Line 35: | Line 35: | ||
*Esmolol | *Esmolol | ||
|- | |- | ||
| − | | β2 || Iso > Epi > | + | | β2 || Iso > Epi > NE || Smooth muscle relaxation || Gs, cAMP up |
| | | | ||
*Albuterol | *Albuterol | ||
| Line 52: | Line 52: | ||
*Labet'''alol''' (anti-α1) | *Labet'''alol''' (anti-α1) | ||
|- | |- | ||
| − | | β3 || Iso > Epi = | + | | β3 || Iso > Epi = NE || Lipolysis, bladder detrusor relaxation || Gs, cAMP up |
| | | | ||
*Mirabegron | *Mirabegron | ||
Revision as of 23:08, 1 February 2023
| Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
|---|---|---|---|---|---|
| α1 | NE > Epi >> Iso | Smooth muscle contraction | Gq, PLC -> IP3/DAG |
|
α1 selective:
|
| α2 | Epi = NE >> Iso | Mixed effects | Gi, presynaptic, cAMP down |
|
Non-selective:
|
| β1 | Iso > NE > Epi | Chronotropy, Inotropy, Amylase secretion | Gs, cAMP up |
|
Cardiac Selective:
|
| β2 | Iso > Epi > NE | Smooth muscle relaxation | Gs, cAMP up |
|
Non-Selective:
|
| β3 | Iso > Epi = NE | Lipolysis, bladder detrusor relaxation | Gs, cAMP up |
|
|