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| ! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists | | ! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists |
| |- | | |- |
− | | α1 || NE > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG | + | | α1 || NE > Epi >> Iso |
| + | | |
| + | *Smooth muscle contraction, ↑SVR, ↑MAP |
| + | *Mydriasis, urethral sphincter contraction |
| + | | |
| + | G<sub>q</sub> → PLC → IP<sub>3</sub>/DAG → [Ca<sup>2+</sup>]<sub>i</sub> |
| | | | | |
| *NE | | *NE |
− | *Phenylephrine | + | *Phenylephrine (pure α1) |
| *Midodrine | | *Midodrine |
| | | | | |
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| *Tamsulosin | | *Tamsulosin |
| |- | | |- |
− | | α2 || Epi = NE >> Iso || Mixed effects || Gi, presynaptic, cAMP down | + | | α2 || Epi = NE >> Iso |
| + | | |
| + | *↑SVR, ↑MAP |
| + | *Decreased insulin release, inhibits lipolysis, decreases aqueous humor production |
| + | | |
| + | presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → inhibition of NT release, sympatholytic effects |
| | | | | |
| *Dexmedetomidine | | *Dexmedetomidine |
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| *Trazodone | | *Trazodone |
| |- | | |- |
− | | β1 || Iso > NE > Epi || Chronotropy, Inotropy, Amylase secretion || Gs, cAMP up | + | | β1 || Iso > NE > Epi |
| + | | |
| + | *↑Chronotropy (myocytes), ↑Inotropy (SA node) →↑CO |
| + | *↑Renin release/↑volume (JGA) |
| + | *Amylase secretion |
| + | | |
| + | G<sub>s</sub> → ↑AC → ↑cAMP |
| | | | | |
| *Dobutamine | | *Dobutamine |