Difference between revisions of "Adrenergic Pharmacology"
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(2 intermediate revisions by the same user not shown) | |||
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*↓insulin release, ↓lipolysis, ↓aqueous humor production | *↓insulin release, ↓lipolysis, ↓aqueous humor production | ||
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− | presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → ↓NT release | + | presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → ↓NT release |
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*Dexmedetomidine | *Dexmedetomidine | ||
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*↑aqueous humor production | *↑aqueous humor production | ||
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− | G<sub>s</sub> → ↑cAMP → ↑PKA | + | G<sub>s</sub> → ↑AC → ↑cAMP → ↑PKA |
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*Albuterol | *Albuterol | ||
Line 76: | Line 76: | ||
*Labet'''alol''' (anti-α1) | *Labet'''alol''' (anti-α1) | ||
|- | |- | ||
− | | β3 || Iso > Epi = NE | | + | | β3 || Iso > Epi = NE |
+ | | | ||
+ | *Lipolysis | ||
+ | *Bladder detrusor relaxation | ||
+ | | | ||
+ | G<sub>s</sub> → ↑AC → ↑cAMP → ↑PKA | ||
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*Mirabegron | *Mirabegron |
Latest revision as of 06:17, 4 February 2023
Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
---|---|---|---|---|---|
α1 | NE > Epi >> Iso |
|
Gq → PLC → IP3/DAG → [Ca2+]i |
|
α1 selective:
|
α2 | Epi = NE >> Iso |
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presynaptic Gi → ↓AC → ↓cAMP → ↓NT release |
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Non-selective:
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β1 | Iso > NE > Epi |
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Gs → ↑AC → ↑cAMP |
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Cardiac Selective:
|
β2 | Iso > Epi > NE |
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Gs → ↑AC → ↑cAMP → ↑PKA |
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Non-Selective:
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β3 | Iso > Epi = NE |
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Gs → ↑AC → ↑cAMP → ↑PKA |
|
|