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*Classification: [[Muscle Relaxers]] > NDMR (quaternary amines) > Aminosteroids (-curONium) > Rapid-onset -curonium (i.e. ROcuronium)
*Classification: [[Muscle Relaxers]] > NDMR (quaternary amines) > Aminosteroids (-curONium) > Rapid-onset -curonium (i.e. ROcuronium)
*Indications: facilitate endotracheal intubation, paralysis
*Indications: facilitate endotracheal intubation, paralysis
*Contraindications: nerve monitoring (e.g. ENT, spinal cases), allergy (NDMR are MCC cause of anaphylaxis in the OR), RSI (relative)
*MOA: Competitive antagonist of ACh, only needs to block one of two ACh binding sites (between α1/δ, α1/γ or α1/ε), causes non-depolarizing paralysis.
*MOA: Competitive antagonist of ACh, only needs to block one of two ACh binding sites (between α1/δ, α1/γ or α1/ε), causes non-depolarizing paralysis.
*Target: N1 (muscle-type) nAChR at the NMJ
*Target: N1 (muscle-type) nAChR at the NMJ