Difference between revisions of "Adrenergic Pharmacology"
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(3 intermediate revisions by the same user not shown) | |||
Line 22: | Line 22: | ||
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*↑SVR, ↑MAP | *↑SVR, ↑MAP | ||
− | * | + | *↓insulin release, ↓lipolysis, ↓aqueous humor production |
| | | | ||
− | presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → | + | presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → ↓NT release |
| | | | ||
*Dexmedetomidine | *Dexmedetomidine | ||
Line 36: | Line 36: | ||
| β1 || Iso > NE > Epi | | β1 || Iso > NE > Epi | ||
| | | | ||
− | *↑Chronotropy (myocytes), ↑Inotropy (SA node) | + | *↑Chronotropy (myocytes), ↑Inotropy (SA node), ↑SBP |
*↑Renin release/↑volume (JGA) | *↑Renin release/↑volume (JGA) | ||
*Amylase secretion | *Amylase secretion | ||
Line 51: | Line 51: | ||
*Esmolol | *Esmolol | ||
|- | |- | ||
− | | β2 || Iso > Epi > NE | | + | | β2 || Iso > Epi > NE |
+ | | | ||
+ | *Smooth muscle relaxation, ↓SVR, ↓DBP, ↓MAP | ||
+ | *Bronchodilation | ||
+ | *↑Lipolysis, ↑Insulin release | ||
+ | *Relax uterine smooth muscle | ||
+ | *↑aqueous humor production | ||
+ | | | ||
+ | G<sub>s</sub> → ↑AC → ↑cAMP → ↑PKA | ||
| | | | ||
*Albuterol | *Albuterol | ||
Line 68: | Line 76: | ||
*Labet'''alol''' (anti-α1) | *Labet'''alol''' (anti-α1) | ||
|- | |- | ||
− | | β3 || Iso > Epi = NE | | + | | β3 || Iso > Epi = NE |
+ | | | ||
+ | *Lipolysis | ||
+ | *Bladder detrusor relaxation | ||
+ | | | ||
+ | G<sub>s</sub> → ↑AC → ↑cAMP → ↑PKA | ||
| | | | ||
*Mirabegron | *Mirabegron |
Latest revision as of 06:17, 4 February 2023
Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
---|---|---|---|---|---|
α1 | NE > Epi >> Iso |
|
Gq → PLC → IP3/DAG → [Ca2+]i |
|
α1 selective:
|
α2 | Epi = NE >> Iso |
|
presynaptic Gi → ↓AC → ↓cAMP → ↓NT release |
|
Non-selective:
|
β1 | Iso > NE > Epi |
|
Gs → ↑AC → ↑cAMP |
|
Cardiac Selective:
|
β2 | Iso > Epi > NE |
|
Gs → ↑AC → ↑cAMP → ↑PKA |
|
Non-Selective:
|
β3 | Iso > Epi = NE |
|
Gs → ↑AC → ↑cAMP → ↑PKA |
|
|