Difference between revisions of "Adrenergic Pharmacology"
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Line 59: | Line 59: | ||
*↑aqueous humor production | *↑aqueous humor production | ||
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− | G<sub>s</sub> → ↑AC | + | G<sub>s</sub> → ↑AC → ↑cAMP → ↑PKA |
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*Albuterol | *Albuterol | ||
Line 81: | Line 81: | ||
*Bladder detrusor relaxation | *Bladder detrusor relaxation | ||
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− | G<sub>s</sub> → ↑AC | + | G<sub>s</sub> → ↑AC → ↑cAMP → ↑PKA |
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*Mirabegron | *Mirabegron |
Latest revision as of 06:17, 4 February 2023
Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
---|---|---|---|---|---|
α1 | NE > Epi >> Iso |
|
Gq → PLC → IP3/DAG → [Ca2+]i |
|
α1 selective:
|
α2 | Epi = NE >> Iso |
|
presynaptic Gi → ↓AC → ↓cAMP → ↓NT release |
|
Non-selective:
|
β1 | Iso > NE > Epi |
|
Gs → ↑AC → ↑cAMP |
|
Cardiac Selective:
|
β2 | Iso > Epi > NE |
|
Gs → ↑AC → ↑cAMP → ↑PKA |
|
Non-Selective:
|
β3 | Iso > Epi = NE |
|
Gs → ↑AC → ↑cAMP → ↑PKA |
|
|