Difference between revisions of "Adrenergic Pharmacology"
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Line 10: | Line 10: | ||
*Midodrine | *Midodrine | ||
| | | | ||
− | + | '''α1 selective:''' | |
− | |||
*Prazosin | *Prazosin | ||
*Tamsulosin | *Tamsulosin | ||
− | |||
|- | |- | ||
| α2 || Epi = Norepi >> Iso || Mixed effects || Gi, presynaptic, cAMP down | | α2 || Epi = Norepi >> Iso || Mixed effects || Gi, presynaptic, cAMP down | ||
Line 21: | Line 19: | ||
*Clonidine | *Clonidine | ||
| | | | ||
+ | '''Non-selective:''' | ||
*Phenoxybenzamine | *Phenoxybenzamine | ||
*Phentolamine | *Phentolamine |
Revision as of 23:05, 1 February 2023
Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
---|---|---|---|---|---|
α1 | Norepi > Epi >> Iso | Smooth muscle contraction | Gq, PLC -> IP3/DAG |
|
α1 selective:
|
α2 | Epi = Norepi >> Iso | Mixed effects | Gi, presynaptic, cAMP down |
|
Non-selective:
|
β1 | Iso > Norepi > Epi | Chronotropy, Inotropy, Amylase secretion | Gs, cAMP up |
|
Cardiac Selective:
|
β2 | Iso > Epi > Norepi | Smooth muscle relaxation | Gs, cAMP up |
|
Non-Selective:
|
β3 | Iso > Epi = Norepi | Lipolysis, bladder detrusor relaxation | Gs, cAMP up |
|
|