Difference between revisions of "OHSU Research Ideas"
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=SCD effects on hemodynamics= | =SCD effects on hemodynamics= | ||
| − | * | + | *[https://www.ima.org.il/FilesUploadPublic/IMAJ/0/384/192227.pdf Moady et al IMAJ 2019]: In healthy volunteers, pneumatic sleeve (PS) compression devices applied to both legs from toe to thigh an inflated to a pressure of 50 or 80 mmHg increased CO, decrease SVR, and have no effect on HR (see ref 16). In CHF patients, the same method does not exacerbate symptoms and increases CO via an increase in SV, decreases SVR, and has no effect on HR (see ref 17). This study however showed that HFrEF patients who were medically optimized had '''no change in any hemodynamic parameter after 60 minutes of PS application''', and that they tolerated it well without any increase in their BNP. |
| − | * | + | *[https://pubmed.ncbi.nlm.nih.gov/25038262/#:~:text=There%20was%20no%20detrimental%20effect,and%20a%20reduction%20in%20SVR. Bickel et al J of Card Failure 2014]: In patients with HFrEF (mean LVEF 30%), ISPC devices applied to both legs and cycled every 2 min for 40 min increased CO, SV, and decreased SVR w/o any effect on HR and without causing signs or symptoms of heart failure exacerbation. CVP and atrial size increased during ISPC activation. |
| − | * | + | *[https://pubmed.ncbi.nlm.nih.gov/31578774/ Gibbons et al Experimental Physiology 2019]: |
| − | * | + | *[https://pubmed.ncbi.nlm.nih.gov/24020667/ Helmi et al Future Cardiology 2013]: |
| − | * | + | *[https://pubmed.ncbi.nlm.nih.gov/21307764/ Kiefer et al Anesthesiology 2011]: |
| − | * | + | *[https://pubmed.ncbi.nlm.nih.gov/20622680/ Kwak et al Journal of Neurosurgical Anesthesiology 2011]: |
| − | * | + | *[https://pubmed.ncbi.nlm.nih.gov/20511029/ Kwak et al Arthroscopy 2010]: |
| − | * | + | *[https://pubmed.ncbi.nlm.nih.gov/18761240/ Fanelli et al Journal of Clinical Anesthesia 2008]: |
| − | * | + | *[https://pubmed.ncbi.nlm.nih.gov/18219162/ Sohn et al Circulation Journal 2008]: |
Revision as of 17:45, 1 August 2023
- Wearable clinical alarms (2 relevant results, 1 highly relevant result)
- VR for IV placement peds (6 articles spanning 2020-2022, 5 RCTs, and a systematic-review and meta-analysis)
- Does change in PPV/CO after SCD activation predict fluid responsiveness and how does it compare to SLR?
- EEG/MEP/SSEP patterns in monkeys/humans taking THC vs controls
- Reversible chemical/optical/electromagnetic knockdown/inhibition/interference of pain nuclei/DRG/dorsal column/STT activity in rodents/primates
- NIBP monitoring from head/neck
- Better way of determining fluid status
- EPIC timeline builder
Resources
- Schnell lab
- Leimer/Lo lab (THC, NHPs)
- Saugstad lab (EVs)
- Schennings (Gas vs. TIVA risk of post-op delirium, assessed via CAM)
- Schulman (interrogate ICDs for EMI after surgery)
- Austin Peters
- Selva Balkan
- Dale Hodges
- Liz Moss
SCD effects on hemodynamics
- Moady et al IMAJ 2019: In healthy volunteers, pneumatic sleeve (PS) compression devices applied to both legs from toe to thigh an inflated to a pressure of 50 or 80 mmHg increased CO, decrease SVR, and have no effect on HR (see ref 16). In CHF patients, the same method does not exacerbate symptoms and increases CO via an increase in SV, decreases SVR, and has no effect on HR (see ref 17). This study however showed that HFrEF patients who were medically optimized had no change in any hemodynamic parameter after 60 minutes of PS application, and that they tolerated it well without any increase in their BNP.
- Bickel et al J of Card Failure 2014: In patients with HFrEF (mean LVEF 30%), ISPC devices applied to both legs and cycled every 2 min for 40 min increased CO, SV, and decreased SVR w/o any effect on HR and without causing signs or symptoms of heart failure exacerbation. CVP and atrial size increased during ISPC activation.
- Gibbons et al Experimental Physiology 2019:
- Helmi et al Future Cardiology 2013:
- Kiefer et al Anesthesiology 2011:
- Kwak et al Journal of Neurosurgical Anesthesiology 2011:
- Kwak et al Arthroscopy 2010:
- Fanelli et al Journal of Clinical Anesthesia 2008:
- Sohn et al Circulation Journal 2008: