November 2026

Lab Vision We explore mechanisms whereby anesthetics lead to amnesia, hypnosis (i.e. impaired behavioral responsiveness), immobility, and analgesia. We develop pharmacologic and device-based methods to modulate components of anesthesia non-invasively.

AY '26-'27 Goals → November Goals

• Submit a manuscript for publication
  • Methohexital data sharing agreement or IRB
  • Ketamine systematic review with Grace/Brian

• Submit RISE 1 application
  • Read CLASS-D papers from Christian
  • Start mining the CLASS-D dataset
  • Talk to Emma about process of getting IRB approval for a study

• Identify additional funding sources and apply
• Start recruiting a research team
  • Lab website
  • Update faculty profile
  • Timeline for matching MD/PhD students

Weekly Summaries

November 5

• Took the day off.
• Teasing out the appropriate interpretation of behavioral screening assays for C. elegans. How do you differentiate if a drug effect is analgesic, paralytic, sedative/hypnotic, or amnestic?
  • Can they be paralyzed with rocuronium? Would it be fatal?
  • Do worms sleep? When? How long? How do you know? What are several ways you might wake them up?
  • What are some learning/memory assays in worms that don't require movement?
  • Paralyze the worms and then see if you can teach them something (e.g. to associate a sound or light with an aversive stimulus)
  • Repeat the experiment with propofol, which we know decreases locomotion.

November 11

• Outline submission guidelines for IJOA (15 minutes)
• Flu shot (15 minutes)
• Demo Respiration.AI hardware (1 hr)
• Ketamine systematic review (2.5 hr)
• SCD-PV systematic review, IRB stuff (1 hr)
• Lab website (1 hr)
• Read CLASS-D papers (1 hr)
• Open and briefly explore CLASS-D data (1 hr) -> 8 hrs total