Adrenergic Pharmacology
Revision as of 06:07, 4 February 2023 by Aesetholephews (talk | contribs)
Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
---|---|---|---|---|---|
α1 | NE > Epi >> Iso |
|
Gq → PLC → IP3/DAG → [Ca2+]i |
|
α1 selective:
|
α2 | Epi = NE >> Iso |
|
presynaptic Gi → ↓AC → ↓cAMP → inhibition of NT release, sympatholytic effects |
|
Non-selective:
|
β1 | Iso > NE > Epi |
|
Gs → ↑AC → ↑cAMP |
|
Cardiac Selective:
|
β2 | Iso > Epi > NE | Smooth muscle relaxation | Gs, cAMP up |
|
Non-Selective:
|
β3 | Iso > Epi = NE | Lipolysis, bladder detrusor relaxation | Gs, cAMP up |
|
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