Opioids
Revision as of 20:50, 31 January 2023 by Aesetholephews (talk | contribs)
Opioid | Dose | Onset | Duration | Elimination | Unique effects/indications |
---|---|---|---|---|---|
Fentanyl | 1-20 ug/kg | 4-6 min | 15-30 min | Hepatic/Renal | Example |
Sufentanyl | 0.3-1 ug/kg | 2-4 min | 5-15 min | Hepatic/Renal | Example |
Remifentanyl | 0.1-0.3 ug/kg | 1-2 min | 2-5 min | Plasma esterases | Example |
Alfentanyl | 15-50 ug/kg | Example | Example | Hepatic/Renal | Example |
Morphine sulfate | 25-75 mg | 10-30 min | 2-5 hrs | Example | Can cause histamine release |
Meperidine | Example | 10-30 min | 2-5 hrs | Example | Used for post-op shivering |
- Don’t combine benzodiazepines and opioids. If you need to reverse, use flumazenil.
- Central loci of opioid action (descending inhibitory pain pathways)
- PAG
- Nucleus Raphe magnus
- Rostral ventromedial medulla
Short-Acting
- Oxycodone, Hydromorphone, Morphine
- Morphine can cause rash/pruritis
Long-Acting
- Oxycodone ER = OxyContin
- Methadone
- Fentanyl is really only used intra-op or in palliative care.