OHSU Research Ideas

• Wearable clinical alarms (2 relevant results, 1 highly relevant result)
• VR for IV placement peds (6 articles spanning 2020-2022, 5 RCTs, and a systematic-review and meta-analysis)
• Does change in PPV/CO after SCD activation predict fluid responsiveness and how does it compare to SLR?
• EEG/MEP/SSEP patterns in monkeys/humans taking THC vs controls
• Reversible chemical/optical/electromagnetic knockdown/inhibition/interference of pain nuclei/DRG/dorsal column/STT activity in rodents/primates
• NIBP monitoring from head/neck
• Better way of determining fluid status
• EPIC timeline builder
• Does sugammadex interfere with HRT in post-menopausal women?
• Which findings on the preop note predict pressors use during the case?

Resources

• Schnell lab
• Leimer/Lo lab (THC, NHPs)
• Saugstad lab (EVs)
• Schennings (Gas vs. TIVA risk of post-op delirium, assessed via CAM)
• Schulman (interrogate ICDs for EMI after surgery)
• Austin Peters
• Selva Balkan
• Dale Hodges
• Liz Moss

SCD hemodynamic effects

Caption text

Reference	Population	Intervention	Comparitor	Outcome
Moady et al IMAJ 2019	Healthy volunteers and HFrEF patients	Pneumatic sleeve (PS) compression devices applied to both legs from toe to thigh and inflated to a pressure of 50 or 80 mmHg. the same method does not exacerbate symptoms and increases CO via an increase in SV, decreases SVR, and has no effect on HR (see ref 17).	Example	In healthy volunteers, there was increased CO, decrease SVR, and have no effect on HR (see ref 16). HFrEF patients who were medically optimized had no change in any hemodynamic parameter after 60 minutes of PS application, and that they tolerated it well without any increase in their BNP.
Bickel et al J of Card Failure 2014	Patients with HFrEF (mean LVEF 30%)	ISPC devices applied to both legs and cycled every 2 min for 40 min.	Example	Increased CO, SV, and decreased SVR w/o any effect on HR and without causing signs or symptoms of heart failure exacerbation. CVP and atrial size increased during ISPC activation.
Gibbons et al Experimental Physiology 2019	Example	Example	Example	Example
Helmi et al Future Cardiology 2013	Example	Example	Example	Example
Kiefer et al Anesthesiology 2011	Example	Example	Example	Example
Kwak et al J of Neurosurgical Anesthesiology 2011	Example	Example	Example	Example
Kwak et al Arthroscopy 2010	Example	Example	Example	Example
Fanelli et al J of Clin Anesthesia 2008	Example	Example	Example	Example
Sohn et al Circulation J 2008	Example	Example	Example	Example