Adrenergic Pharmacology
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Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
---|---|---|---|---|---|
α1 | NE > Epi >> Iso |
|
Gq → PLC → IP3/DAG → [Ca2+]i |
|
α1 selective:
|
α2 | Epi = NE >> Iso |
|
presynaptic Gi → ↓AC → ↓cAMP → ↓NT release |
|
Non-selective:
|
β1 | Iso > NE > Epi |
|
Gs → ↑AC → ↑cAMP |
|
Cardiac Selective:
|
β2 | Iso > Epi > NE |
|
Gs → ↑AC → ↑cAMP → ↑PKA |
|
Non-Selective:
|
β3 | Iso > Epi = NE |
|
Gs → ↑AC → ↑cAMP → ↑PKA |
|
|