Bohr Effect Modulation
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The Bohr effect facilitates the release of oxygen in the tissues, particularly in tissues with the highest metabolic demand. When a tissue's metabolic rate increases, so does its carbon dioxide waste production. When released into the bloodstream, carbon dioxide forms bicarbonate and protons--facilitated by carbonic anhydrase (present in RBCs)--causing the pH to decrease and promoting dissociation of O2 from Hgb.