| *** Renal: bilateral [[RAS]], [[PKD]], [[CKD]] | | *** Renal: bilateral [[RAS]], [[PKD]], [[CKD]] |
| *** Other: [[Cocaine]], [[OSA]], [[OCPs]], [[Coarctation]] | | *** Other: [[Cocaine]], [[OSA]], [[OCPs]], [[Coarctation]] |
− | ** Tx: For SBP 121-139 or DBP 81-89, start with 8-12 weeks lifestyle modifications and reassess. Can start with 1 or 2 agents depending on severity. First line: ACEI/ARB (good for kidney protection), Dihydropyridine CCB > non-dihydropyridine CCB, Beta Blockers (cardiac selective (MAN BABES) > non-selective), Thiazide-Like Diuretics > Thiazide-Type Diuretics. Special populations: CHF (avoid CCBs, use beta blockers), CKD (use ACEI/ARB), Pregnancy (hydralazine, labetalol, nicardipine, methyldopa), post-MI (use beta blockers + ACEI/ARB), Blacks (CCB + thiazide-like diuretic) | + | ** Tx: For SBP 121-139 or DBP 81-89, start with 8-12 weeks lifestyle modifications and reassess. When starting medication, start with 1 or 2 agents depending on severity, reassess efficacy every month and up the dose or add another agent as needed. ACEI/ARB (good for kidney protection), Dihydropyridine CCB > non-dihydropyridine CCB, Beta Blockers (cardiac selective (MAN BABES) > non-selective), Thiazide-Like Diuretics > Thiazide-Type Diuretics. For most patients, the combination of ACEI/ARB + CCB is the best, so start with one of these two classes so that the second can be added later for synergy. Special population considerations: CHF (avoid CCBs, use beta blockers), CKD (use ACEI/ARB), Pregnancy (hydralazine, labetalol, nicardipine, methyldopa), post-MI (use beta blockers + ACEI/ARB), Blacks (CCB + thiazide-like diuretic), Cocaine (don't give beta blockers due to unopposed alpha). |