1,022
edits
Changes
Jump to navigation
Jump to search
Line 120:
Line 120: − + − + − + − + − + − +
→Neuromuscular Junction
=Neuromuscular Junction=
=Neuromuscular Junction=
==Myasthenia Gravis==
==Myasthenia Gravis==
*H&P:
*H&P: Autoantibodies against AChR, presents with muscle weakness that worsens as the day progresses and improves after sleep. May have positive family history.
*Dx:
*Dx: Look for ptosis that improves with ice pack test. Edrophonium test is positive. EMG shows unstable baseline between APs.
*Tx:
*Tx: Pyridostigmine.
==Lambert Eaton Myasthenia==
==Lambert Eaton Myasthenia==
*H&P:
*H&P: Autoantibodies against pre-synaptic voltage-gated Ca2+ channels. Improves with exercise.
*Dx:
*Dx: Negative edrophonium test. Associated with small-cell lung cancer.
*Tx:
*Tx: Plasmapheresis or IVIG.
=Muscle=
=Muscle=