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Adrenergic Pharmacology (view source)
Revision as of 23:00, 1 February 2023
, 23:00, 1 February 2023no edit summary
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists
|-
|-
| Alpha-1 || Norepi > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG
| α1 || Norepi > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG
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*Norepi
*Norepi
*Trazodone
*Trazodone
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|-
| Alpha-2 || Epi = Norepi >> Iso || Mixed effects || Gi, presynaptic, cAMP down
| α2 || Epi = Norepi >> Iso || Mixed effects || Gi, presynaptic, cAMP down
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*Dexmedetomidine
*Dexmedetomidine
*Trazodone
*Trazodone
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|-
| Beta-1 || Iso > Norepi > Epi || Example || Gs, cAMP up
| β1 || Iso > Norepi > Epi || Chronotropy, Inotropy, Amylase secretion || Gs, cAMP up
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*Dobutamine
*Dobutamine
*Esmolol
*Esmolol
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|-
| Beta-2 || Iso > Epi > Norepi || Example || Gs, cAMP up
| β2 || Iso > Epi > Norepi || Smooth muscle relaxation || Gs, cAMP up
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*Albuterol
*Albuterol
*Pindolol
*Pindolol
*Timolol
*Timolol
*Carved'''ilol''' (anti-α1)
*Labet'''alol''' (anti-α1)
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|-
| Beta-3 || Iso > Epi = Norepi || Example || Gs, cAMP up
| β3 || Iso > Epi = Norepi || Lipolysis, bladder detrusor relaxation || Gs, cAMP up
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*Mirabegron
*Mirabegron
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*SR 59230A
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|}