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Created page with "*Classification: Muscle Relaxers > NDMR (quaternary amines) > Aminosteroids (-curONium) > Rapid-onset -curonium (i.e. ROcuronium) *Indications: facilitate endotracheal intubat..."
*Classification: Muscle Relaxers > NDMR (quaternary amines) > Aminosteroids (-curONium) > Rapid-onset -curonium (i.e. ROcuronium)
*Indications: facilitate endotracheal intubation, paralysis
*MOA: Competitive antagonist of ACh, only needs to block one of two ACh binding sites (between α1/δ, α1/γ or α1/ε), causes non-depolarizing paralysis.
*Target: N1 (muscle-type) nAChR at the NMJ
*Dose: 0.45-0.9 (normal induction), or 0.6-1.2 (RSI)
*Onset: 0.5-1.5 min
*Duration: 30-60 min (activators of CYP450 such as AEDs can markedly decrease duration of action)
*Clearance: Hepato-biliary (70%), Renal (10%)
*Reversal: Suggamadex (neostigmine)
*Other: Weak vagolytic effect
*Indications: facilitate endotracheal intubation, paralysis
*MOA: Competitive antagonist of ACh, only needs to block one of two ACh binding sites (between α1/δ, α1/γ or α1/ε), causes non-depolarizing paralysis.
*Target: N1 (muscle-type) nAChR at the NMJ
*Dose: 0.45-0.9 (normal induction), or 0.6-1.2 (RSI)
*Onset: 0.5-1.5 min
*Duration: 30-60 min (activators of CYP450 such as AEDs can markedly decrease duration of action)
*Clearance: Hepato-biliary (70%), Renal (10%)
*Reversal: Suggamadex (neostigmine)
*Other: Weak vagolytic effect