Changes

| [https://pubmed.ncbi.nlm.nih.gov/25038262/#:~:text=There%20was%20no%20detrimental%20effect,and%20a%20reduction%20in%20SVR. Bickel et al J of Card Failure 2014] || Patients with HFrEF (mean LVEF 30%) || ISPC devices applied to both legs and cycled every 2 min for 40 min. || Example || Increased CO, SV, and decreased SVR w/o any effect on HR and without causing signs or symptoms of heart failure exacerbation. CVP and atrial size increased during ISPC activation.

| [https://pubmed.ncbi.nlm.nih.gov/25038262/#:~:text=There%20was%20no%20detrimental%20effect,and%20a%20reduction%20in%20SVR. Bickel et al J of Card Failure 2014] || Patients with HFrEF (mean LVEF 30%) || ISPC devices applied to both legs and cycled every 2 min for 40 min. || Example || Increased CO, SV, and decreased SVR w/o any effect on HR and without causing signs or symptoms of heart failure exacerbation. CVP and atrial size increased during ISPC activation.

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| [https://pubmed.ncbi.nlm.nih.gov/31578774/ Gibbons et al Experimental Physiology 2019] || 14 healthy university students; || Four 3 minute trials of orthostatic maneuvers (stand-to-squat or thigh cuff compression/release) were done in random order with half of the trials involving ISPC (5 cuffs, peristaltic motion, applied over 200 ms, 65 mmHg, timed to local diastolic phase) of the lower extremity timed to counteract orthostatic changes (return to standing or after thigh-cuff release). Hemodynamic parameters were measured with ultrasound and other non-invasive monitors before, during, and after || Example || Example

| [https://pubmed.ncbi.nlm.nih.gov/31578774/ Gibbons et al Experimental Physiology 2019] || 14 healthy university students; || Four 3 minute trials of orthostatic maneuvers (stand-to-squat or thigh cuff compression/release) were done in random order with half of the trials involving ISPC (5 cuffs, peristaltic motion, applied over 200 ms, 65 mmHg, timed to local diastolic phase) of the lower extremity timed to counteract orthostatic changes (return to standing or after thigh-cuff release). Hemodynamic parameters (superficial femoral artery, MAP, Doppler ultrasound cardiac output, total peripheral resistance, middle cerebral artery blood velocity (MCAv), and cerebral tissue saturation index) were measured non-invasively before, during, and after || Example || Decreased TPR, heart rate; increased CO (via increased SV), TSI, and MCAv

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| [https://pubmed.ncbi.nlm.nih.gov/24020667/ Helmi et al Future Cardiology 2013] || Example || Example || Example || Example

| [https://pubmed.ncbi.nlm.nih.gov/24020667/ Helmi et al Future Cardiology 2013] || Example || Example || Example || Example