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Anesthetics and Uterine Tone (view source)
Revision as of 21:59, 14 September 2022
, 21:59, 14 September 2022Created page with "* All volatile anesthetics cause a dose-dependent decrease in uterine tone. ** Act on GABA1 receptors, and voltage sensitive Ca2+, and Na+ channels. ** Doses higher than 0.75..."
* All volatile anesthetics cause a dose-dependent decrease in uterine tone.
** Act on GABA1 receptors, and voltage sensitive Ca2+, and Na+ channels.
** Doses higher than 0.75 MAC causes atony.
** Before delivery in a C-section, gas is titrated to 1.0 MAC to avoid maternal awareness, but is downtitrated after delivery.
* N2O, opioids, and ketamine have minimal effect, unless used at high doses.
* Propofol instead of inhaled anesthetics may reduce bleeding according to a systematic review and meta-analysis of 4 RCTs between 1997 and 2015, however, the quality of the evidence was rated as very low.
** Act on GABA1 receptors, and voltage sensitive Ca2+, and Na+ channels.
** Doses higher than 0.75 MAC causes atony.
** Before delivery in a C-section, gas is titrated to 1.0 MAC to avoid maternal awareness, but is downtitrated after delivery.
* N2O, opioids, and ketamine have minimal effect, unless used at high doses.
* Propofol instead of inhaled anesthetics may reduce bleeding according to a systematic review and meta-analysis of 4 RCTs between 1997 and 2015, however, the quality of the evidence was rated as very low.