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Intrathecal morphine pump and total pancreatectomy with autologous islet cell transplant both lead to clinically significant pain relief and decreased MME requirement in chronic pancreatitis. Surgical treatment, even with islet cell transplant, has increased risk of developing post-operative insulin-dependent diabetes.
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[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1080%2f19490976.2024.2310291 Prescription opioids induced microbial dysbiosis worsens severity of chronic pancreatitis and drives pain hypersensitivity]
 
[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&DO=10.1080%2f19490976.2024.2310291 Prescription opioids induced microbial dysbiosis worsens severity of chronic pancreatitis and drives pain hypersensitivity]
  

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