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Line 9: − + − − '''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med21&DO=10.1002%2fadvs.202104136 Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges. [Review]]''' − − Source − Advanced science. 9(13):e2104136, 2022 05. − − Authors − Zafonte RD; Wang L; Arbelaez CA; Dennison R; Teng YD − − Abstract − Gaseous molecules have been increasingly explored for therapeutic development. Here, following an analytical background introduction, a systematic review of medical gas research is presented, focusing on tissue protections, mechanisms, data tangibility, and translational challenges. The pharmacological efficacies of carbon monoxide (CO) and xenon (Xe) are further examined with emphasis on intracellular messengers associated with cytoprotection and functional improvement for the CNS, heart, retina, liver, kidneys, lungs, etc. Overall, the outcome supports the hypothesis that readily deliverable "biological gas" (CO, H2 , H2 S, NO, O2 , O3 , and N2 O) or "noble gas" (He, Ar, and Xe) treatment may preserve cells against common pathologies by regulating oxidative, inflammatory, apoptotic, survival, and/or repair processes. Specifically, CO, in safe dosages, elicits neurorestoration via igniting sGC/cGMP/MAPK signaling and crosstalk between HO-CO, HIF-1alpha/VEGF, and NOS pathways. Xe rescues neurons through NMDA antagonism and PI3K/Akt/HIF-1alpha/ERK activation. Primary findings also reveal that the need to utilize cutting-edge molecular and genetic tactics to validate mechanistic targets and optimize outcome consistency remains urgent; the number of neurotherapeutic investigations is limited, without published results from large in vivo models. Lastly, the broad-spectrum, concurrent multimodal homeostatic actions of medical gases may represent a novel pharmaceutical approach to treating critical organ failure and neurotrauma. Copyright © 2022 The Authors. Advanced Science published by Wiley-VCH GmbH. − − Publication Type − Journal Article. Review. Systematic Review. Research Support, Non-U.S. Gov't. − − Year of Publication − 2022 − − − '''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.23736%2fS0375-9393.18.12909-9 Xenon anesthesia and beyond: pros and cons. [Review]]''' − − Source − Minerva Anestesiologica. 85(1):83-89, 2019 01. − − Authors − Jin Z; Piazza O; Ma D; Scarpati G; De Robertis E − − Abstract − Xenon is a colorless and odorless noble gas, licensed for human use as an anesthetic gas as well as a radiological marker. The MAC of this gas is about 63% but xenon anesthesia is associated with fast recovery of cognitive function and cardiovascular stability. Nevertheless, postoperative nausea and vomiting (PONV) incidence for xenon anesthesia is very high. It has been reported that Xenon has cytoprotective effects that may have therapeutic values in both CNS protection, and in organ graft preservation. Currently, there are few studies about the effect of xenon on ischemia reperfusion injury of transplantable organs and insufficient clinical data upon its effect on intracranial and cerebral perfusion pressure. We shortly review the pros and cons of xenon as an anesthetic agent. − − Publication Type − Journal Article. Review. − − Year of Publication − 2019
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7 2 or 3 or 4 or 5 or 6 (851731)
7 2 or 3 or 4 or 5 or 6 (851731)
8 1 and 7 (119)
8 1 and 7 (119)
9 from 8 keep 8,14-15,17-19,21,37-38,51,57,111,115 (13)
9 from 8 keep 15,17-19,21,37-38,51,57,111,115 (13)
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'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fanie.201909544 Xenon Recovery by DD3R Zeolite Membranes: Application in Anaesthetics. [Review]]'''
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fanie.201909544 Xenon Recovery by DD3R Zeolite Membranes: Application in Anaesthetics. [Review]]'''