Adrenergic Pharmacology
Revision as of 23:08, 1 February 2023 by Aesetholephews (talk | contribs)
Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
---|---|---|---|---|---|
α1 | NE > Epi >> Iso | Smooth muscle contraction | Gq, PLC -> IP3/DAG |
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α1 selective:
|
α2 | Epi = NE >> Iso | Mixed effects | Gi, presynaptic, cAMP down |
|
Non-selective:
|
β1 | Iso > NE > Epi | Chronotropy, Inotropy, Amylase secretion | Gs, cAMP up |
|
Cardiac Selective:
|
β2 | Iso > Epi > NE | Smooth muscle relaxation | Gs, cAMP up |
|
Non-Selective:
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β3 | Iso > Epi = NE | Lipolysis, bladder detrusor relaxation | Gs, cAMP up |
|
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