Bohr Effect Modulation

The Bohr effect facilitates the release of oxygen in the tissues, particularly in tissues with the highest metabolic demand. When a tissue's metabolic rate increases, so does its carbon dioxide waste production. When released into the bloodstream, carbon dioxide forms bicarbonate and protons—facilitated by carbonic anhydrase (present in RBCs)—causing the pH to decrease and promoting dissociation of O2 from Hgb.