Anticoagulation

• Better to use unfractionated heparin in patients with impaired renal function.
• LMWH has lower risk of HIT
• Protamine reverses unfractionated heparin.
• Heparin MOA is to enhance the action of anti-thrombin, which inhibits X and thrombin.
• TXA inhibits plasmin.
• Hemophelia
• vWD
• Umbilical cord and head bleeds indicates factor 13 deficiency.
• Cryo includes factors 8 and 13, fibrinogen, and vWF.
• FEIBA (factor eight inhibitor bypass agent)
• alpha and dense granules are in platelets
• ADAMTS13 deficiency leads to TTP.