Diuretics
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| Class | Site of action | Examples | Na Reabsorption |
|---|---|---|---|
| Carbonic anhydrase inhibitors | Proximal convoluted tubule | Acetazolamide | 69% |
| Loop | Thick ascending limb of loop of Henle | Furosemide, Bumetanide | 20% |
| Thiazide | Distal convoluted tubule | Metolazone, Chlorthalidone, Chlorothiazide (diuril) | 3-8% |
| Potassium sparing | Collecting duct | Spironolactone, Amiloride | 2-3% |
Sequential nephron blockade involves choosing multiple diuretics with different sites of action, avoid blocking all four segments though.