NSAIDs
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- e.g. Ibuprofen, Naproxen, Ketorolac
- Renally excreted. Acts on COX 1/2. Inhibits renal production of prostaglandins.
- Safe for short term use in patients with stage 1-2 CKD. Risk of causing AKI is same as in general population. No evidence that it will increase risk of progression.
- Schedule NSAIDs, if they are only PRNs they likely won’t happen.
- Topical = Diclofenac gel (Voltaren).