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| ** Most Common Etiologies | | ** Most Common Etiologies |
| *** '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm | | *** '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm |
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| ** Pathogenesis | | ** Pathogenesis |
| *** Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway) | | *** Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway) |
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| *** Platelets are trapped in the clots | | *** Platelets are trapped in the clots |
| *** Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]]. | | *** Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]]. |
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| ** Diagnostic Algorithm: Score of 5+ points strongly associated with DIC | | ** Diagnostic Algorithm: Score of 5+ points strongly associated with DIC |
| *** Presence of a disease known to be associated with DIC (2 pts) | | *** Presence of a disease known to be associated with DIC (2 pts) |
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| *** PT > 3s (1 pt), > 6s (2 pt) | | *** PT > 3s (1 pt), > 6s (2 pt) |
| *** Fibrinogen < 1 g/L (1 pt) | | *** Fibrinogen < 1 g/L (1 pt) |
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| ** Treatments and Evidence Behind Them: | | ** Treatments and Evidence Behind Them: |
| *** Basically don't get it. | | *** Basically don't get it. |
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| *** Treatment is lousy. Evidence behind treatment is likewise lousy. | | *** Treatment is lousy. Evidence behind treatment is likewise lousy. |
| *** Platelets, cryo, FFP | | *** Platelets, cryo, FFP |
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| ** Morbidity/Mortality is 20-50% | | ** Morbidity/Mortality is 20-50% |
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