Thrombocytopenia
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Platelets come from megakariocytes and are produced in bone marrow and lung. Their development is stimulated by thrombopoeitin produced in liver and kidney. They are 2-3 um across. Platelet function follows the pattern: Adhesion -> Activation -> Aggregation. Platelet aggregation forms a platelet plug (primary hemostasis), which is stabilized by coagulation factors culminating in a fibrin mesh/net which stabilizes the platelet plug.
Spurious
- Clumping
Sequestration
- Hypersplenism
Destruction/Consumption
- HIGH IPF%, Prolonged PT / aPTT
- What happens to platelets after they help form a clot?
- DIC
- ITP
- TTP
- HUS
- HIT
Decreased Production
- LOW IPF%
- Parvo
- Aplastic Anemia
- Cancer
- Chemotherapy
- Liver disease?