Difference between revisions of "Diuretics"
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| Line 8: | Line 8: | ||
| Loop || Thick ascending limb of loop of Henle || Furosemide, Bumetanide || 20% | | Loop || Thick ascending limb of loop of Henle || Furosemide, Bumetanide || 20% | ||
|- | |- | ||
| − | | Thiazide || Distal convoluted tubule || Metolazone, Chlorthalidone || 3-8% | + | | Thiazide || Distal convoluted tubule || Metolazone, Chlorthalidone, Chlorothiazide (diuril) || 3-8% |
|- | |- | ||
| Potassium sparing || Collecting duct || Spironolactone, Amiloride || 2-3% | | Potassium sparing || Collecting duct || Spironolactone, Amiloride || 2-3% | ||
Latest revision as of 13:08, 30 April 2023
| Class | Site of action | Examples | Na Reabsorption |
|---|---|---|---|
| Carbonic anhydrase inhibitors | Proximal convoluted tubule | Acetazolamide | 69% |
| Loop | Thick ascending limb of loop of Henle | Furosemide, Bumetanide | 20% |
| Thiazide | Distal convoluted tubule | Metolazone, Chlorthalidone, Chlorothiazide (diuril) | 3-8% |
| Potassium sparing | Collecting duct | Spironolactone, Amiloride | 2-3% |
Sequential nephron blockade involves choosing multiple diuretics with different sites of action, avoid blocking all four segments though.