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→HIT
=HIT=
=Thrombocytopenia=
==ITP==
*H&P: Caused by autoantibodies against platelet membrane proteins.
*Dx: Low platelets with otherwise normal labs. Petechiae and purpura.
*Tx: Corticosteroids if Plt < 30k
==TTP==
*H&P:
*Dx: Low platelets plus microangiopathic hemolytic anemia with low Hgb, shistocytes on smear, elevated LDH. Sometimes associated with acute renal failure (hemolytic uremic syndrome)
*Tx: Treat HUS with plasma exchange
==DIC==
*H&P: Spontaneous bleeding due to widespread intravascular coagulation and consumption of clotting factors.
*Dx: Low platelets plus elevated d-dimer, prolonged PT/PTT, low fibrinogen
==HIT==
*Tx: Discontinuation of heparin and transition to a DOAC if anticoagulation is still required (Warfarin causes transient hyper coagulable state due to '''depletion of protein of C'''). '''Avoidance of heparin for life'''
*Tx: Discontinuation of heparin and transition to a DOAC if anticoagulation is still required (Warfarin causes transient hyper coagulable state due to '''depletion of protein of C'''). '''Avoidance of heparin for life'''