NSAIDs

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  • e.g. Ibuprofen, Naproxen, Ketorolac
  • Renal excretion. Acts on COX 1/2. Inhibits renal production of prostaglandins.
  • Safe for short term use in patients with stage 1-2 CKD. Risk of causing AKI is same as in general population. No evidence that it will increase risk of progression.
  • Schedule NSAIDs, if they are only PRNs they likely won’t happen.