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Line 10: − − ** Most Common Etiologies − *** '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm − ** Pathogenesis − *** Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway) − *** Consumption of clotting factors − *** Widespread micro and macrovascular thrombosis, depletion of fibrinogen and fibrin clot formation − *** Platelets are trapped in the clots − *** Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]]. − ** Diagnostic Algorithm: Score of 5+ points strongly associated with DIC − *** Presence of a disease known to be associated with DIC (2 pts) − *** Platelets < 100k (1 pt), < 50k (2 pt) − *** Fibrin degradation products (FDPs) (e.g. d-dimer): moderate increase (2 pt), strong increase (3 pt) − *** PT > 3s (1 pt), > 6s (2 pt) − *** Fibrinogen < 1 g/L (1 pt) − ** Treatments and Evidence Behind Them: − *** Basically don't get it. − *** Treat underlying condition − *** Treatment is lousy. Evidence behind treatment is likewise lousy. − *** Platelets, cryo, FFP − ** Morbidity/Mortality is 20-50% −
→Destruction/Consumption
* '''HIGH''' IPF%, Prolonged PT / aPTT
* '''HIGH''' IPF%, Prolonged PT / aPTT
* What happens to platelets after they help form a clot?
* What happens to platelets after they help form a clot?
* [[DIC]]
* [[DIC]]
* ITP
* ITP
* TTP
* TTP